BDBM50459922 Ansofaxine::LPM-570065::LPM570065::LY-03005::Ly03005::ODVP2

SMILES CN(C)CC(c1ccc(OC(=O)c2ccc(C)cc2)cc1)C1(O)CCCCC1

InChI Key InChIKey=QKYBZJLEMOZFFU-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50459922   

TargetSodium-dependent dopamine transporter(Human)
Biocon Bristol-Myers Squibb R&D Centre

Curated by ChEMBL
LigandPNGBDBM50459922(Ansofaxine | LPM-570065 | LPM570065 | LY-03005 | L...)
Affinity DataIC50: 491nMAssay Description:Inhibition of human DAT expressed in CHO cells assessed as reduction of [3H]-DA re-uptake preincubated for 10 mins followed by [3H]-DA addition measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Biocon Bristol-Myers Squibb R&D Centre

Curated by ChEMBL
LigandPNGBDBM50459922(Ansofaxine | LPM-570065 | LPM570065 | LY-03005 | L...)
Affinity DataIC50: 491nMAssay Description:Binding affinity to DAT (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Biocon Bristol-Myers Squibb R&D Centre

Curated by ChEMBL
LigandPNGBDBM50459922(Ansofaxine | LPM-570065 | LPM570065 | LY-03005 | L...)
Affinity DataIC50: 723nMAssay Description:Binding affinity to SERT (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Biocon Bristol-Myers Squibb R&D Centre

Curated by ChEMBL
LigandPNGBDBM50459922(Ansofaxine | LPM-570065 | LPM570065 | LY-03005 | L...)
Affinity DataIC50: 723nMAssay Description:Inhibition of human SERT expressed in CHO cells assessed as reduction of [3H]-5-HT re-uptake preincubated for 10 mins followed by [3H]-5-HT addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Biocon Bristol-Myers Squibb R&D Centre

Curated by ChEMBL
LigandPNGBDBM50459922(Ansofaxine | LPM-570065 | LPM570065 | LY-03005 | L...)
Affinity DataIC50: 763nMAssay Description:Inhibition of human NET expressed in CHO cells assessed as reduction of [3H]-NE re-uptake preincubated for 10 mins followed by [3H]-NE addition measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Biocon Bristol-Myers Squibb R&D Centre

Curated by ChEMBL
LigandPNGBDBM50459922(Ansofaxine | LPM-570065 | LPM570065 | LY-03005 | L...)
Affinity DataIC50: 763nMAssay Description:Binding affinity to NET (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed