BDBM50460429 CHEMBL4229142

SMILES ONC(=O)c1ccc(\C=C\C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)Nc2ccc(Cl)cc2)cc1

InChI Key InChIKey=JXKIBHDACODLNS-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50460429   

TargetHistone deacetylase(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50460429(CHEMBL4229142)
Affinity DataIC50: 5.70nMAssay Description:Inhibition of HDAC in human HeLa cell nuclear extract using Boc-Lys (acetyl)-AMC as substrate preincubated for 5 mins followed by substrate addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50460429(CHEMBL4229142)
Affinity DataIC50: 13nMAssay Description:Inhibition of HDAC6 (unknown origin) using Ac-Leu-GlyLys(Ac)-AMC as substrate preincubated for 5 mins followed by substrate addition measured after 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetHistone deacetylase 11(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50460429(CHEMBL4229142)
Affinity DataIC50: 16nMAssay Description:Inhibition of HDAC11 (unknown origin) using Ac-Leu-GlyLys(Ac)-AMC as substrate preincubated for 5 mins followed by substrate addition measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50460429(CHEMBL4229142)
Affinity DataIC50: 47nMAssay Description:Inhibition of HDAC8 (unknown origin) using Ac-Leu-GlyLys(Ac)-AMC as substrate preincubated for 5 mins followed by substrate addition measured after 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50460429(CHEMBL4229142)
Affinity DataIC50: 55nMAssay Description:Inhibition of HDAC1 (unknown origin) using Ac-Leu-GlyLys(Ac)-AMC as substrate preincubated for 5 mins followed by substrate addition measured after 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed