BindingDB BDBM50463479 CHEMBL4249925

BDBM50463479 CHEMBL4249925

SMILES CS(=O)(=O)Nc1cccc(CC(=O)Nc2nc(cs2)-c2c[nH]c3ncccc23)c1

InChI Key InChIKey=HIUHVDROHDSKTC-UHFFFAOYSA-N

Data 139 KI 3 IC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 142 hits for monomerid = 50463479

Rho-associated protein kinase 1(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463479(CHEMBL4249925)

Ki: 2nMAssay Description:Inhibition of ROCK1 (6 to 553 residues) (unknown origin) using Lys-Lys-Arg-Asn-Arg-Thr-Leu-Ser-Val as substrate in presence of ATP by spectrophotomet...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed PDB

3D Structure (crystal)

Rho-associated protein kinase 2(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463479(CHEMBL4249925)

Ki: <4nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Rho-associated protein kinase 1(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463479(CHEMBL4249925)

Ki: 6nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed PDB

3D Structure (crystal)

Serine/threonine-protein kinase N2(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463479(CHEMBL4249925)

Ki: 77nMAssay Description:Inhibition of PRK2 (unknown origin)More data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Ribosomal protein S6 kinase alpha-5(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463479(CHEMBL4249925)

Ki: 94nMAssay Description:Inhibition of MSK1 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Ribosomal protein S6 kinase alpha-1/alpha-2/alpha-3/alpha-4/alpha-5/alpha-6/beta-1/beta-2(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463479(CHEMBL4249925)

Ki: 100nMAssay Description:Inhibition of p70S6K (unknown origin)More data for this Ligand-Target Pair

PDB MMDB KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Citron Rho-interacting kinase(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463479(CHEMBL4249925)

Ki: 160nMAssay Description:Inhibition of CIT (unknown origin)More data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Protein kinase C gamma type(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463479(CHEMBL4249925)

Ki: 210nMAssay Description:Inhibition of PKCgamma (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463479(CHEMBL4249925)

Ki: 250nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Tyrosine-protein kinase JAK3(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463479(CHEMBL4249925)

Ki: 280nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Protein kinase C theta type(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463479(CHEMBL4249925)

Ki: 290nMAssay Description:Inhibition of PKCtheta (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Tyrosine-protein kinase JAK2(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463479(CHEMBL4249925)

Ki: 400nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Glycogen synthase kinase-3 beta(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463479(CHEMBL4249925)

Ki: 400nMAssay Description:Inhibition of GSK3beta (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Protein kinase C epsilon type(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463479(CHEMBL4249925)

Ki: 690nMAssay Description:Inhibition of PKCepsilon (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Mitogen-activated protein kinase 1(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463479(CHEMBL4249925)

Ki: 890nMAssay Description:Inhibition of Erk2 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Ribosomal protein S6 kinase alpha-2(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463479(CHEMBL4249925)

Ki: 940nMAssay Description:Inhibition of RSK3 (unknown origin)More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Mitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463479(CHEMBL4249925)

Ki: >1.00E+3nMAssay Description:Inhibition of MAP4K4 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Dual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463479(CHEMBL4249925)

Ki: 1.00E+3nMAssay Description:Inhibition of DYRK1A (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Serine/threonine-protein kinase D2(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463479(CHEMBL4249925)

Ki: >1.00E+3nMAssay Description:Inhibition of PRKD2 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

PAS domain-containing serine/threonine-protein kinase(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463479(CHEMBL4249925)

Ki: >1.00E+3nMAssay Description:Inhibition of PASK (unknown origin)More data for this Ligand-Target Pair

PDB MMDB KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Dual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463479(CHEMBL4249925)

Ki: >1.00E+3nMAssay Description:Inhibition of MEK1 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Misshapen-like kinase 1(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463479(CHEMBL4249925)

Ki: >1.00E+3nMAssay Description:Inhibition of MINK (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Cyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463479(CHEMBL4249925)

Ki: 1.30E+3nMAssay Description:Inhibition of CDK5/p35 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463479(CHEMBL4249925)

Ki: 1.50E+3nMAssay Description:Inhibition of CDK2/CycA (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Interleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463479(CHEMBL4249925)

Ki: 1.90E+3nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Tyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463479(CHEMBL4249925)

Ki: >2.00E+3nMAssay Description:Inhibition of ZAP70 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Insulin-like growth factor 1 receptor(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463479(CHEMBL4249925)

Ki: >2.00E+3nMAssay Description:Inhibition of IGF1R (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Fibroblast growth factor receptor 2(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463479(CHEMBL4249925)

Ki: >2.00E+3nMAssay Description:Inhibition of FGFR2 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Mitogen-activated protein kinase 13(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463479(CHEMBL4249925)

Ki: >2.00E+3nMAssay Description:Inhibition of p38delta (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Ribosomal protein S6 kinase alpha-1(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463479(CHEMBL4249925)

Ki: >2.00E+3nMAssay Description:Inhibition of RSK1 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Dual specificity protein kinase CLK3(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463479(CHEMBL4249925)

Ki: >2.00E+3nMAssay Description:Inhibition of CLK3 (unknown origin)More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Serine/threonine-protein kinase PAK 3(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463479(CHEMBL4249925)

Ki: >2.00E+3nMAssay Description:Inhibition of PAK3 (unknown origin)More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Phosphorylase b kinase gamma catalytic chain, liver/testis isoform(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463479(CHEMBL4249925)

Ki: >2.00E+3nMAssay Description:Inhibition of PHKgamma2 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Serine/threonine-protein kinase pim-2(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463479(CHEMBL4249925)

Ki: >2.00E+3nMAssay Description:Inhibition of Pim2 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Calcium/calmodulin-dependent protein kinase type II subunit beta(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463479(CHEMBL4249925)

Ki: >2.00E+3nMAssay Description:Inhibition of CamK2B (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Calcium/calmodulin-dependent protein kinase type II subunit beta(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463479(CHEMBL4249925)

Ki: >2.00E+3nMAssay Description:Inhibition of CamK2 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Serine/threonine-protein kinase Chk1(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463479(CHEMBL4249925)

Ki: >2.00E+3nMAssay Description:Inhibition of CheK1 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Serine/threonine-protein kinase Chk2(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463479(CHEMBL4249925)

Ki: >2.00E+3nMAssay Description:Inhibition of CheK2 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Tyrosine-protein kinase CSK(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463479(CHEMBL4249925)

Ki: >2.00E+3nMAssay Description:Inhibition of CSK (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Ephrin type-B receptor 2(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463479(CHEMBL4249925)

Ki: >2.00E+3nMAssay Description:Inhibition of EphB2 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Vascular endothelial growth factor receptor 3(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463479(CHEMBL4249925)

Ki: >2.00E+3nMAssay Description:Inhibition of FLT4 (unknown origin)More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Tyrosine-protein kinase Fyn(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463479(CHEMBL4249925)

Ki: >2.00E+3nMAssay Description:Inhibition of FYN (unknown origin)More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Serine/threonine-protein kinase MARK1(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463479(CHEMBL4249925)

Ki: >2.00E+3nMAssay Description:Inhibition of MARK1 (unknown origin)More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Serine/threonine-protein kinase D3(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463479(CHEMBL4249925)

Ki: >2.00E+3nMAssay Description:Inhibition of PRKD3 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Serine/threonine-protein kinase Sgk2(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463479(CHEMBL4249925)

Ki: >2.00E+3nMAssay Description:Inhibition of SGK2 (unknown origin)More data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Testis-specific serine/threonine-protein kinase 2(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463479(CHEMBL4249925)

Ki: >2.00E+3nMAssay Description:Inhibition of TSSK2 (unknown origin)More data for this Ligand-Target Pair

KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Tyrosine-protein kinase Yes(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463479(CHEMBL4249925)

Ki: >2.00E+3nMAssay Description:Inhibition of YES (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Dual specificity mitogen-activated protein kinase kinase 7(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463479(CHEMBL4249925)

Ki: >2.00E+3nMAssay Description:Inhibition of MKK7 (unknown origin)More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Mitogen-activated protein kinase 12(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463479(CHEMBL4249925)

Ki: >2.00E+3nMAssay Description:Inhibition of p38gamma (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Tyrosine-protein kinase ABL1(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463479(CHEMBL4249925)

Ki: >2.00E+3nMAssay Description:Inhibition of Abl1 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Displayed 1 to 50 (of 142 total ) | Next | Last >>

Filter my 142 hits

Targets 136▿
- Calcium/calmodulin-dependent protein kinase type II subunit beta 2
- Serine/threonine-protein kinase TBK1 2
- Protein kinase C beta type 2
- Rho-associated protein kinase 1 2
- Serine/threonine-protein kinase Sgk1 2
- Cytochrome P450 3A4 2
- Hepatocyte growth factor receptor 1
- Glycogen synthase kinase-3 beta 1
- Protein kinase C iota type 1
- Receptor-type tyrosine-protein kinase FLT3 1
- Serine/threonine-protein kinase Nek2 1
- Serine/threonine-protein kinase Nek1 1
- Macrophage-stimulating protein receptor 1
- Choline kinase alpha 1
- Sphingosine kinase 1 1
- MAP/microtubule affinity-regulating kinase 3 1
- Serine/threonine-protein kinase PAK 1 1
- Protein kinase C theta type 1
- Serine/threonine-protein kinase PAK 2 1
- Serine/threonine-protein kinase PAK 3 1
- Tyrosine-protein kinase JAK3 1
- Dual specificity mitogen-activated protein kinase kinase 1 1
- Tyrosine-protein kinase JAK2 1
- Proto-oncogene tyrosine-protein kinase receptor Ret 1
- Dual specificity mitogen-activated protein kinase kinase 6 1
- Ceramide kinase 1
- Dual specificity mitogen-activated protein kinase kinase 7 1
- Tyrosine-protein kinase ZAP-70 1
- Serine/threonine-protein kinase Sgk2 1
- Serine/threonine-protein kinase Sgk3 1
- Tyrosine-protein kinase BTK 1
- Ephrin type-A receptor 4 1
- Tyrosine-protein kinase ITK/TSK 1
- DNA-dependent protein kinase catalytic subunit 1
- Insulin-like growth factor 1 receptor 1
- Tyrosine-protein kinase Blk 1
- Epidermal growth factor receptor 1
- Cyclin-A2/Cyclin-dependent kinase 2 1
- RAF proto-oncogene serine/threonine-protein kinase 1
- Tyrosine-protein kinase Lyn 1
- Focal adhesion kinase 1 1
- Ephrin type-B receptor 4 1
- Ephrin type-B receptor 2 1
- MAP kinase-activated protein kinase 2 1
- MAP kinase-activated protein kinase 5 1
- Death-associated protein kinase 1 1
- Tyrosine-protein kinase Fer 1
- Serine/threonine-protein kinase D2 1
- Serine/threonine-protein kinase D3 1
- Serine/threonine-protein kinase D1 1
- PAS domain-containing serine/threonine-protein kinase 1
- Proto-oncogene tyrosine-protein kinase ROS 1
- Dual specificity tyrosine-phosphorylation-regulated kinase 1A 1
- Serine/threonine-protein kinase pim-1 1
- Serine/threonine-protein kinase DCLK1 1
- Serine/threonine-protein kinase pim-2 1
- Serine/threonine-protein kinase DCLK2 1
- Angiopoietin-1 receptor 1
- Protein kinase C epsilon type 1
- Testis-specific serine/threonine-protein kinase 2 1
- Mast/stem cell growth factor receptor Kit 1
- Mitogen-activated protein kinase kinase kinase kinase 4 1
- Mitogen-activated protein kinase 14 1
- Serine/threonine-protein kinase ATR 1
- Cyclin-dependent kinase 5 activator 1 1
- Interleukin-1 receptor-associated kinase 4 1
- Cytoplasmic tyrosine-protein kinase BMX 1
- RAC-gamma serine/threonine-protein kinase 1
- Interleukin-1 receptor-associated kinase 1 1
- Mitogen-activated protein kinase kinase kinase 8 1
- Mitogen-activated protein kinase kinase kinase 7 1
- Tyrosine-protein kinase ABL1 1
- RAC-alpha serine/threonine-protein kinase 1
- Calcium/calmodulin-dependent protein kinase type II subunit alpha 1
- Ribosomal protein S6 kinase alpha-1/alpha-2/alpha-3/alpha-4/alpha-5/alpha-6/beta-1/beta-2 1
- Rho-associated protein kinase 2 1
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 1
- Proto-oncogene tyrosine-protein kinase Src 1
- Tyrosine-protein kinase Fes/Fps 1
- Mitogen-activated protein kinase 1 1
- Serine/threonine-protein kinase 3 1
- Tyrosine-protein kinase Lck 1
- Mitogen-activated protein kinase 3 1
- Serine/threonine-protein kinase 4 1
- Mitogen-activated protein kinase kinase kinase 14 1
- Dual specificity protein kinase CLK3 1
- Protein-tyrosine kinase 2-beta 1
- Tyrosine-protein kinase Mer 1
- Serine/threonine-protein kinase N2 1
- Potassium voltage-gated channel subfamily H member 2 1
- Mitogen-activated protein kinase 8 1
- Calcium/calmodulin-dependent protein kinase type IV 1
- Ribosomal protein S6 kinase alpha-2 1
- Tyrosine-protein kinase SYK 1
- Ribosomal protein S6 kinase alpha-3 1
- Ribosomal protein S6 kinase alpha-1 1
- Phosphorylase b kinase gamma catalytic chain, liver/testis isoform 1
- Calcium/calmodulin-dependent protein kinase type 1D 1
- Fibroblast growth factor receptor 4 1
- Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 1
- Aurora kinase B 1
- Vascular endothelial growth factor receptor 2 1
- Insulin receptor 1
- Vascular endothelial growth factor receptor 3 1
- Tyrosine-protein kinase HCK 1
- Aurora kinase A 1
- Fibroblast growth factor receptor 1 1
- Fibroblast growth factor receptor 2 1
- Aurora kinase C 1
- Fibroblast growth factor receptor 3 1
- Vascular endothelial growth factor receptor 1 1
- Serine/threonine-protein kinase PLK1 1
- Inhibitor of nuclear factor kappa-B kinase subunit beta 1
- Mitogen-activated protein kinase 13 1
- Inhibitor of nuclear factor kappa-B kinase subunit alpha 1
- Mitogen-activated protein kinase 12 1
- Tyrosine-protein kinase receptor TYRO3 1
- Mitogen-activated protein kinase 11 1
- RAC-beta serine/threonine-protein kinase 1
- Mitogen-activated protein kinase 10 1
- Serine/threonine-protein kinase BRSK1 1
- Casein kinase I isoform alpha 1
- Protein kinase C gamma type 1
- Misshapen-like kinase 1 1
- Tyrosine-protein kinase Fyn 1
- Tyrosine-protein kinase CSK 1
- Macrophage colony-stimulating factor 1 receptor 1
- Citron Rho-interacting kinase 1
- Platelet-derived growth factor receptor alpha 1
- Ribosomal protein S6 kinase alpha-5 1
- Serine/threonine-protein kinase BRSK2 1
- Serine/threonine-protein kinase Chk2 1
- Serine/threonine-protein kinase MARK1 1
- Serine/threonine-protein kinase Chk1 1
- Tyrosine-protein kinase Yes 1
- Dual specificity tyrosine-phosphorylation-regulated kinase 2 1
Publications 2▿
- Bioorg Med Chem Lett 28: 2622-2626 (2018) 139
- Bioorg Med Chem Lett 33: (2021) 3
Institutions 1▿
- Vertex Pharmaceuticals 142
Affinity: 2 to 3.0E+4 nM▿
- Ki 139
- IC50 3
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 0
Catalog Cmpds: 0