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BDBM50464218 CHEMBL4237599

SMILES: CCC(CC)Nc1nc(Nc2ccc(F)c(Cl)c2)nc2ccccc12

InChI Key: InChIKey=MMMLOSDFXADVIH-UHFFFAOYSA-N

Data: 1 EC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50464218   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Son of sevenless homolog 1


(Homo sapiens (Human))
BDBM50464218
PNG
(CHEMBL4237599)
Show SMILES CCC(CC)Nc1nc(Nc2ccc(F)c(Cl)c2)nc2ccccc12
Show InChI InChI=1S/C19H20ClFN4/c1-3-12(4-2)22-18-14-7-5-6-8-17(14)24-19(25-18)23-13-9-10-16(21)15(20)11-13/h5-12H,3-4H2,1-2H3,(H2,22,23,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 2.19E+4n/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Activation of SOS1 in human HeLa cells assessed as increase in RAS-GTP levels after 30 mins by pull-down assay


ACS Med Chem Lett 9: 941-946 (2018)


Article DOI: 10.1021/acsmedchemlett.8b00296
BindingDB Entry DOI: 10.7270/Q2MS3WDD
More data for this
Ligand-Target Pair