BDBM50465213 CHEMBL4294359::US10766903, Example 11

SMILES C[C@H](CC(=O)N1CCC(O)(Cn2cnc(NCCN3CCCC3)cc2=O)CC1)c1ccccc1

InChI Key InChIKey=VJDZJAUBPMXVAF-OAQYLSRUSA-N

Data  2 IC50  1 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50465213   

TargetUbiquitin carboxyl-terminal hydrolase 7(Homo sapiens (Human))
Almac Discovery

Curated by ChEMBL
LigandPNGBDBM50465213(CHEMBL4294359 | US10766903, Example 11)
Affinity DataIC50:  90nMAssay Description:Inhibition of USP7 (unknown origin) by biochemical assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetUbiquitin carboxyl-terminal hydrolase 7(Homo sapiens (Human))
Almac Discovery

Curated by ChEMBL
LigandPNGBDBM50465213(CHEMBL4294359 | US10766903, Example 11)
Affinity DataIC50: <250nMAssay Description:USP7 activity was monitored in a fluorescence polarisation (FP) homogeneous assay using the isopeptide ubiquitin-Lys-TAMRA substrate (U-558, Boston B...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetUbiquitin carboxyl-terminal hydrolase 7(Homo sapiens (Human))
Almac Discovery

Curated by ChEMBL
LigandPNGBDBM50465213(CHEMBL4294359 | US10766903, Example 11)
Affinity DataEC50:  320nMAssay Description:Inhibition of USP7 in human HCT116 cells using ubiquitin-propargylamine probe as substrate incubated for 2 hrs followed by substrate addition measure...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB