BDBM50465586 CHEMBL4294174::US10501466, Example B14

SMILES COc1cc(ccc1C)C(=O)N[C@@H]1CCCc2ccc(cc12)-c1cn2CCCc2n1

InChI Key InChIKey=HMOMQPHKMPWUKJ-OAQYLSRUSA-N

Data  3 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50465586   

TargetWD repeat-containing protein 5(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50465586(CHEMBL4294174 | US10501466, Example B14)
Affinity DataKi:  9.40nMAssay Description:Binding affinity to N-terminal 6x-His-SUMO tagged WDR5 delta23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli BL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetWD repeat-containing protein 5(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50465586(CHEMBL4294174 | US10501466, Example B14)
Affinity DataKi:  26.8nMAssay Description:A fluorescence polarization anisotropy (FPA) assay that measures the displacement of either a FITC-labeled MLL-derived peptide or a more potent 10mer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetWD repeat-containing protein 5(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50465586(CHEMBL4294174 | US10501466, Example B14)
Affinity DataKi:  27nMAssay Description:Binding affinity to N-terminal 6x-His-SUMO tagged WDR5 delta23 deletion mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli BL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetWD repeat-containing protein 5(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50465586(CHEMBL4294174 | US10501466, Example B14)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human WDR5 (22 to 334 residues) assessed as reduction in WRAD-mediated human MLL1 ( 3745 to 3969 residues) H3K4 methylation using human...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed