BDBM50468247 HM 781-36B::HM-781-36B::NOV-120101::Poziotinib::US11365189, Ex. No. 36::US11896597, Compound Poziotinib

SMILES: COc1cc2ncnc(Nc3ccc(Cl)c(Cl)c3F)c2cc1OC1CCN(CC1)C(=O)C=C

InChI Key: InChIKey=LPFWVDIFUFFKJU-UHFFFAOYSA-N

Data: 28 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 28 hits for monomerid = 50468247   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Human)	BDBM50468247 (HM 781-36B | HM-781-36B | NOV-120101 | Poziotinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM50468247 (HM 781-36B | HM-781-36B | NOV-120101 | Poziotinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	915	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM50468247 (HM 781-36B | HM-781-36B | NOV-120101 | Poziotinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.262	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2 (Human)	BDBM50468247 (HM 781-36B | HM-781-36B | NOV-120101 | Poziotinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM50468247 (HM 781-36B | HM-781-36B | NOV-120101 | Poziotinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	197	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM50468247 (HM 781-36B | HM-781-36B | NOV-120101 | Poziotinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.151	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM50468247 (HM 781-36B | HM-781-36B | NOV-120101 | Poziotinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.137	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM50468247 (HM 781-36B | HM-781-36B | NOV-120101 | Poziotinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.0610	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM50468247 (HM 781-36B | HM-781-36B | NOV-120101 | Poziotinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.270	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2 (Human)	BDBM50468247 (HM 781-36B | HM-781-36B | NOV-120101 | Poziotinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM50468247 (HM 781-36B | HM-781-36B | NOV-120101 | Poziotinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.218	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM50468247 (HM 781-36B | HM-781-36B | NOV-120101 | Poziotinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.0780	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM50468247 (HM 781-36B | HM-781-36B | NOV-120101 | Poziotinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.0780	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM50468247 (HM 781-36B | HM-781-36B | NOV-120101 | Poziotinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.218	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [1-773,'NPH',774-1210] (Human)	BDBM50468247 (HM 781-36B | HM-781-36B | NOV-120101 | Poziotinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM50468247 (HM 781-36B | HM-781-36B | NOV-120101 | Poziotinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2 (Human)	BDBM50468247 (HM 781-36B | HM-781-36B | NOV-120101 | Poziotinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM50468247 (HM 781-36B | HM-781-36B | NOV-120101 | Poziotinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [1-769,'SV',770-1210] (Human)	BDBM50468247 (HM 781-36B | HM-781-36B | NOV-120101 | Poziotinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [1-769,'SVD',770-1210] (Human)	BDBM50468247 (HM 781-36B | HM-781-36B | NOV-120101 | Poziotinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [1-770,'NPG',771-1210] (Human)	BDBM50468247 (HM 781-36B | HM-781-36B | NOV-120101 | Poziotinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [1-770,'SVD',771-1210] (Human)	BDBM50468247 (HM 781-36B | HM-781-36B | NOV-120101 | Poziotinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [S768I] (Human)	BDBM50468247 (HM 781-36B | HM-781-36B | NOV-120101 | Poziotinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.910	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM50468247 (HM 781-36B | HM-781-36B | NOV-120101 | Poziotinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Human)	BDBM50468247 (HM 781-36B | HM-781-36B | NOV-120101 | Poziotinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2 [1-775,'YVMA',776-1255] (Human)	BDBM50468247 (HM 781-36B | HM-781-36B | NOV-120101 | Poziotinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [T790M,L858R] (Human)	BDBM50468247 (HM 781-36B | HM-781-36B | NOV-120101 | Poziotinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Epidermal growth factor receptor [1-769,'ASV',770-1210] (Human)	BDBM50468247 (HM 781-36B | HM-781-36B | NOV-120101 | Poziotinib ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair