BDBM50492496 Cabotegravir::GSK-1265744A::GSK1265744::GSK1265744A::S-265744

SMILES [H][C@@]12Cn3cc(C(=O)NCc4ccc(F)cc4F)c(=O)c(O)c3C(=O)N1[C@@H](C)CO2

InChI Key InChIKey=WCWSTNLSLKSJPK-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50492496   

TargetIntegrase(Human immunodeficiency virus type 1)
University of Rwanda

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50492496BDBM50492496(Cabotegravir | GSK-1265744A | GSK1265744 | GSK1265...)
Affinity DataIC50: 0.220nMAssay Description:Inhibition of KDR (unknown origin) in cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
University of Rwanda

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50492496BDBM50492496(Cabotegravir | GSK-1265744A | GSK1265744 | GSK1265...)
Affinity DataIC50: 0.340nMAssay Description:Inhibition of KDR (unknown origin) in cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Glaxosmithkline Research & Development

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50492496BDBM50492496(Cabotegravir | GSK-1265744A | GSK1265744 | GSK1265...)
Affinity DataIC50: 3nMAssay Description:Inhibition of HIV-1 integrase strand transfer activity using [3H]-DNA as substrate preincubated for 60 mins prior to substrate addition measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
University of Rwanda

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50492496BDBM50492496(Cabotegravir | GSK-1265744A | GSK1265744 | GSK1265...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of HIV-1 integrase strand transfer activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed