BDBM50505821 CHEMBL4457343

SMILES COc1cc(NC(C)=O)c(O)c2nccc(-c3ccccc3NC(=O)c3ccccc3)c12

InChI Key InChIKey=MDEKTLHANMKMTR-UHFFFAOYSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50505821   

TargetDNA topoisomerase 2-alpha(Human)
Colorado State University

Curated by ChEMBL
LigandPNGBDBM50505821(CHEMBL4457343)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of human topoisomerase 2alpha mediated decatenation using kDNA as susbtrate preincubated for 20 mins followed by substrate and ATP additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha(Human)
Colorado State University

Curated by ChEMBL
LigandPNGBDBM50505821(CHEMBL4457343)
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of topoisomerase 2alpha dependent TCF transcription in human SW620 organoids transduced with TOPflash luminescent reporter after 72 hrs by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha(Human)
Colorado State University

Curated by ChEMBL
LigandPNGBDBM50505821(CHEMBL4457343)
Affinity DataEC50:  4.00E+3nMAssay Description:Inhibition of topoisomerase 2alpha in human SW620 organoids transfected with VimPro-GFP reporter assessed as reversion of epithelial-mesenchymal tran...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetDNA topoisomerase 2-alpha(Human)
Colorado State University

Curated by ChEMBL
LigandPNGBDBM50505821(CHEMBL4457343)
Affinity DataEC50:  9.00E+3nMAssay Description:Inhibition of topoisomerase 2alpha in human SW620 organoids transfected with EcadPro-RFP reporter assessed as reversion of epithelial-mesenchymal tra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed