BDBM50506474 Ft-2102::Olutasidenib::US11311527, Cpd ID 1::US11376246, Compound 1::US11566013, Compound I-1

SMILES: C[C@@H](C1=Cc2cc(ccc2NC1=O)Cl)NC3=CC=C(N(C3=O)C)C#N

InChI Key: InChIKey=NEQYWYXGTJDAKR-UHFFFAOYSA-N

Data: 32 IC50

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 33 hits for monomerid = 50506474   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Isocitrate dehydrogenase [NADP], mitochondrial (Human)	BDBM50506474 (Ft-2102 | Olutasidenib | US11376246, Compound 1 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.73E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Isocitrate dehydrogenase [NADP] cytoplasmic [R132S] (Human)	BDBM50506474 (Ft-2102 | Olutasidenib | US11376246, Compound 1 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic [R132H] (Human)	BDBM50506474 (Ft-2102 | Olutasidenib | US11376246, Compound 1 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	21.2	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Isocitrate dehydrogenase [NADP] cytoplasmic [R132C] (Human)	BDBM50506474 (Ft-2102 | Olutasidenib | US11376246, Compound 1 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	114	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic (Human)	BDBM50506474 (Ft-2102 | Olutasidenib | US11376246, Compound 1 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic (Human)	BDBM50506474 (Ft-2102 | Olutasidenib | US11376246, Compound 1 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	114	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic (Human)	BDBM50506474 (Ft-2102 | Olutasidenib | US11376246, Compound 1 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic (Human)	BDBM50506474 (Ft-2102 | Olutasidenib | US11376246, Compound 1 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	39	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic (Human)	BDBM50506474 (Ft-2102 | Olutasidenib | US11376246, Compound 1 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
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Isocitrate dehydrogenase [NADP] cytoplasmic [R132L] (Human)	BDBM50506474 (Ft-2102 | Olutasidenib | US11376246, Compound 1 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Isocitrate dehydrogenase [NADP], mitochondrial (Human)	BDBM50506474 (Ft-2102 | Olutasidenib | US11376246, Compound 1 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic (Human)	BDBM50506474 (Ft-2102 | Olutasidenib | US11376246, Compound 1 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	42	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic (Human)	BDBM50506474 (Ft-2102 | Olutasidenib | US11376246, Compound 1 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.24E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic (Human)	BDBM50506474 (Ft-2102 | Olutasidenib | US11376246, Compound 1 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic (Human)	BDBM50506474 (Ft-2102 | Olutasidenib | US11376246, Compound 1 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic (Human)	BDBM50506474 (Ft-2102 | Olutasidenib | US11376246, Compound 1 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	94	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic (Human)	BDBM50506474 (Ft-2102 | Olutasidenib | US11376246, Compound 1 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic [R132H] (Human)	BDBM50506474 (Ft-2102 | Olutasidenib | US11376246, Compound 1 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	21.2	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic [R132G] (Human)	BDBM50506474 (Ft-2102 | Olutasidenib | US11376246, Compound 1 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic [R132C] (Human)	BDBM50506474 (Ft-2102 | Olutasidenib | US11376246, Compound 1 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic [R132H] (Human)	BDBM50506474 (Ft-2102 | Olutasidenib | US11376246, Compound 1 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Isocitrate dehydrogenase [NADP], mitochondrial [R140Q] (Human)	BDBM50506474 (Ft-2102 | Olutasidenib | US11376246, Compound 1 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Isocitrate dehydrogenase [NADP], mitochondrial [R172K] (Human)	BDBM50506474 (Ft-2102 | Olutasidenib | US11376246, Compound 1 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic (Human)	BDBM50506474 (Ft-2102 | Olutasidenib | US11376246, Compound 1 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	922	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic [R132C] (Human)	BDBM50506474 (Ft-2102 | Olutasidenib | US11376246, Compound 1 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic [R132H] (Human)	BDBM50506474 (Ft-2102 | Olutasidenib | US11376246, Compound 1 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic [R132C] (Human)	BDBM50506474 (Ft-2102 | Olutasidenib | US11376246, Compound 1 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	67.1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic [R132H] (Human)	BDBM50506474 (Ft-2102 | Olutasidenib | US11376246, Compound 1 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	12.9	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic [R132C] (Human)	BDBM50506474 (Ft-2102 | Olutasidenib | US11376246, Compound 1 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	77	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic [R132H] (Human)	BDBM50506474 (Ft-2102 | Olutasidenib | US11376246, Compound 1 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	14.3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic [R132C] (Human)	BDBM50506474 (Ft-2102 | Olutasidenib | US11376246, Compound 1 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.22E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic [R132H] (Human)	BDBM50506474 (Ft-2102 | Olutasidenib | US11376246, Compound 1 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	21.2	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Isocitrate dehydrogenase [NADP] cytoplasmic [R132C] (Human)	BDBM50506474 (Ft-2102 | Olutasidenib | US11376246, Compound 1 | ...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.22E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair