BDBM50514200 CHEMBL4446378::US10703733, Comparative Example 1

SMILES: C[C@H]1C/C=C/[C@@H]([C@@H]2CC[C@H]2C[N@@]3C[C@@]4(CCCc5c4ccc(c5)Cl)COc6c3cc(cc6)C(=O)NS(=O)(=O)[C@@H]1C)OC

InChI Key: InChIKey=JQNINBDKGLWYMU-UHFFFAOYSA-N

Data: 8 KI  4 IC50

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50514200   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Bcl-2-like protein 11 [51-76]/Induced myeloid leukemia cell differentiation protein Mcl-1 [171-327] (Human)	BDBM50514200 (US10703733, Comparative Example 1 | CHEMBL4446378) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
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Apoptosis regulator Bcl-2 (Human)	BDBM50514200 (US10703733, Comparative Example 1 | CHEMBL4446378) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.93E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Bcl-2-like protein 1 (Human)	BDBM50514200 (US10703733, Comparative Example 1 | CHEMBL4446378) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.42E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Induced myeloid leukemia cell differentiation protein Mcl-1 (Human)	BDBM50514200 (US10703733, Comparative Example 1 | CHEMBL4446378) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
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Induced myeloid leukemia cell differentiation protein Mcl-1 (Human)	BDBM50514200 (US10703733, Comparative Example 1 | CHEMBL4446378) Show SMILES Show InChI	GoogleScholar	UniChem		0.0600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Induced myeloid leukemia cell differentiation protein Mcl-1 (Human)	BDBM50514200 (US10703733, Comparative Example 1 | CHEMBL4446378) Show SMILES Show InChI	GoogleScholar	UniChem		0.0600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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G1/S-specific cyclin-D1 (Human)	BDBM50514200 (US10703733, Comparative Example 1 | CHEMBL4446378) Show SMILES Show InChI	GoogleScholar	UniChem		0.0600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Induced myeloid leukemia cell differentiation protein Mcl-1 (Human)	BDBM50514200 (US10703733, Comparative Example 1 | CHEMBL4446378) Show SMILES Show InChI	GoogleScholar	UniChem		0.0760	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Induced myeloid leukemia cell differentiation protein Mcl-1 (Human)	BDBM50514200 (US10703733, Comparative Example 1 | CHEMBL4446378) Show SMILES Show InChI	GoogleScholar	UniChem		60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Bcl-2-like protein 1 (Human)	BDBM50514200 (US10703733, Comparative Example 1 | CHEMBL4446378) Show SMILES Show InChI	GoogleScholar	UniChem		700	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Bcl-2-like protein 1 (Human)	BDBM50514200 (US10703733, Comparative Example 1 | CHEMBL4446378) Show SMILES Show InChI	GoogleScholar	UniChem		700	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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Apoptosis regulator Bcl-2 (Human)	BDBM50514200 (US10703733, Comparative Example 1 | CHEMBL4446378) Show SMILES Show InChI	GoogleScholar	UniChem		950	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Human)	BDBM50514200 (US10703733, Comparative Example 1 | CHEMBL4446378) Show SMILES Show InChI	GoogleScholar	UniChem		950	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair