BDBM50514902 CHEMBL4476380::US12110278, Compound 10

SMILES: c1cc(ccc1NC(=O)n2c(nc(n2)Nc3ccc(cc3)S(=O)(=O)N)N)OCC(=O)O

InChI Key: InChIKey=QQXWNIAQCDPFCH-UHFFFAOYSA-N

Data: 2 IC50  10 Kd

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50514902   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 [536-812,W659A,W777A,F794H] (Human)	BDBM50514902 (CHEMBL4476380 | US12110278, Compound 10) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	571	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132] (Human)	BDBM50514902 (CHEMBL4476380 | US12110278, Compound 10) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	4.23E+4	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [536-812,W659A,W777A,F794H] (Human)	BDBM50514902 (CHEMBL4476380 | US12110278, Compound 10) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	570	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [536-812,W659A,W777A,F794H] (Human)	BDBM50514902 (CHEMBL4476380 | US12110278, Compound 10) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	310	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [536-812,V617F,W659A,W777A,F794H] (Human)	BDBM50514902 (CHEMBL4476380 | US12110278, Compound 10) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	540	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 [536-812,V617F,W659A,W777A,F794H] (Human)	BDBM50514902 (CHEMBL4476380 | US12110278, Compound 10) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM50514902 (CHEMBL4476380 | US12110278, Compound 10) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	4.23E+4	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM50514902 (CHEMBL4476380 | US12110278, Compound 10) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	310	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM50514902 (CHEMBL4476380 | US12110278, Compound 10) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM50514902 (CHEMBL4476380 | US12110278, Compound 10) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.65E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM50514902 (CHEMBL4476380 | US12110278, Compound 10) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	540	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Human)	BDBM50514902 (CHEMBL4476380 | US12110278, Compound 10) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	571	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair