BDBM50518770 CHEMBL4456157

SMILES COc1cc(F)cc2c3c(nn(C)c3nnc12)-c1ccncc1C

InChI Key InChIKey=BEHIYTQDLXFKJV-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50518770   

LigandPNGBDBM50518770(CHEMBL4456157)
Affinity DataIC50: 21nMAssay Description:Inhibition of recombinant human N-terminal His-tagged PDE10A2 expressed in HEK293 cells using cAMP as substrate measured after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Abbvie Deutschland

Curated by ChEMBL
LigandPNGBDBM50518770(CHEMBL4456157)
Affinity DataIC50: 3.52E+3nMAssay Description:Inhibition of human PDE2A using cAMP as substrate measured after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Abbvie Deutschland

Curated by ChEMBL
LigandPNGBDBM50518770(CHEMBL4456157)
Affinity DataIC50: 8.52E+3nMAssay Description:Inhibition of human GST-tagged PDE3A (484 to end residues) using cAMP as substrate measured after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Abbvie Deutschland

Curated by ChEMBL
LigandPNGBDBM50518770(CHEMBL4456157)
Affinity DataIC50: 9.54E+3nMAssay Description:Inhibition of human full-length PDE4D2 expressed in Sf9 insect cells using cAMP as substrate measured after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Abbvie Deutschland

Curated by ChEMBL
LigandPNGBDBM50518770(CHEMBL4456157)
Affinity DataIC50: 1.73E+4nMAssay Description:Inhibition of human ERG expressed in HEK293 cells by Qpatch methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed