BDBM50521331 CHEMBL4557373::US11311528, Ex. 1-85

SMILES CC(C)(C)c1ccc(cc1Cl)N1[C@@H]([C@@H](CC(O)=O)c2ccc(F)cc2C1=O)c1ccc2OCCOc2c1

InChI Key InChIKey=JAIAHSWXASHNQH-CCLHPLFOSA-N

Data  3 IC50  1 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50521331   

LigandPNGBDBM50521331(CHEMBL4557373 | US11311528, Ex. 1-85)
Affinity DataIC50:  68nMAssay Description:Displacement of [3H]cGAMP from full length human HAQ STING expressed in Trichopulsia ni membranes preincubated for 30 mins followed by [3H]cGAMP addi...More data for this Ligand-Target Pair
LigandPNGBDBM50521331(CHEMBL4557373 | US11311528, Ex. 1-85)
Affinity DataIC50:  68nMAssay Description:The ability of compounds to bind STING is quantified by their ability to compete with tritiated cGAMP ligand for human STING receptor membrane using ...More data for this Ligand-Target Pair
LigandPNGBDBM50521331(CHEMBL4557373 | US11311528, Ex. 1-85)
Affinity DataIC50:  1.10E+4nMAssay Description:Antagonist activity at STING in human THP1 cells assessed as inhibition of cGAMP-induced IFNbeta production pretreated for 6 hrs followed by cGAMP ad...More data for this Ligand-Target Pair
LigandPNGBDBM50521331(CHEMBL4557373 | US11311528, Ex. 1-85)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at STING in human THP1 cells assessed as stimulation of IFNbeta production measured after 5 hrs by Alphalisa assayMore data for this Ligand-Target Pair