BDBM50521331 CHEMBL4557373::US11311528, Ex. 1-85
SMILES CC(C)(C)c1ccc(cc1Cl)N1[C@@H]([C@@H](CC(O)=O)c2ccc(F)cc2C1=O)c1ccc2OCCOc2c1
InChI Key InChIKey=JAIAHSWXASHNQH-CCLHPLFOSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 50521331
Affinity DataIC50: 68nMAssay Description:Displacement of [3H]cGAMP from full length human HAQ STING expressed in Trichopulsia ni membranes preincubated for 30 mins followed by [3H]cGAMP addi...More data for this Ligand-Target Pair
TargetStimulator of interferon genes protein [1-379,R71H,G230A,H232R,R293Q](Human)
Merck Sharp & Dohme
US Patent
Merck Sharp & Dohme
US Patent
Affinity DataIC50: 68nMAssay Description:The ability of compounds to bind STING is quantified by their ability to compete with tritiated cGAMP ligand for human STING receptor membrane using ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+4nMAssay Description:Antagonist activity at STING in human THP1 cells assessed as inhibition of cGAMP-induced IFNbeta production pretreated for 6 hrs followed by cGAMP ad...More data for this Ligand-Target Pair
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at STING in human THP1 cells assessed as stimulation of IFNbeta production measured after 5 hrs by Alphalisa assayMore data for this Ligand-Target Pair