BDBM50522312 CHEMBL4560452

SMILES COc1ccc(cc1)S(=O)(=O)N1C(=O)NC2(CCCc3ccccc23)C1=O

InChI Key InChIKey=KQNAXJYPBMYCPP-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50522312   

TargetAldo-keto reductase family 1 member B1(Human)
Quaid-I-Azam University

Curated by ChEMBL
LigandPNGBDBM50522312(CHEMBL4560452)
Affinity DataIC50: 1.17E+4nMAssay Description:Inhibition of human recombinant ALR2 expressed in Escherichia coli using DL-glyceraldehyde as substrate and NADPH preincubated for 5 mins followed by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Rat)
Quaid-I-Azam University

Curated by ChEMBL
LigandPNGBDBM50522312(CHEMBL4560452)
Affinity DataIC50: 1.58E+4nMAssay Description:Inhibition of ALR2 in rat lens assessed as reduction in sorbitol accumulation incubated for 3 hrs in presence of 28 mM glucose by gas chromatographic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Rat)
Quaid-I-Azam University

Curated by ChEMBL
LigandPNGBDBM50522312(CHEMBL4560452)
Affinity DataIC50: 1.94E+4nMAssay Description:Inhibition of ALR2 in rat sciatic nerve assessed as reduction in sorbitol accumulation incubated for 3 hrs in presence of 28 mM glucose by gas chroma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Rat)
Quaid-I-Azam University

Curated by ChEMBL
LigandPNGBDBM50522312(CHEMBL4560452)
Affinity DataIC50: 2.04E+4nMAssay Description:Inhibition of ALR2 in rat erythrocytes assessed as reduction in sorbitol accumulation incubated for 3 hrs in presence of 28 mM glucose by gas chromat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetAldo-keto reductase family 1 member B1(Rat)
Quaid-I-Azam University

Curated by ChEMBL
LigandPNGBDBM50522312(CHEMBL4560452)
Affinity DataIC50: 2.56E+4nMAssay Description:Inhibition of rat kidney ALR1 using DL-glyceraldehyde as substrate and NADPH preincubated for 5 mins followed by substrate addition and measured for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed