BDBM50524300 LY2606368::Prexasertib::US11564920, Example Prexasertib

SMILES: COc1cccc(OCCCN)c1-c1cc(Nc2cnc(cn2)C#N)n[nH]1

InChI Key: InChIKey=DOTGPNHGTYJDEP-UHFFFAOYSA-N

Data: 19 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 50524300   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-dependent kinase 2 (Human)	BDBM50524300 (LY2606368 | Prexasertib | US11564920, Example Prex...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Serine/threonine-protein kinase Chk2 (Human)	BDBM50524300 (LY2606368 | Prexasertib | US11564920, Example Prex...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Chk1 (Human)	BDBM50524300 (LY2606368 | Prexasertib | US11564920, Example Prex...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Chk2 (Human)	BDBM50524300 (LY2606368 | Prexasertib | US11564920, Example Prex...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Chk1 (Human)	BDBM50524300 (LY2606368 | Prexasertib | US11564920, Example Prex...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Chk1 (Human)	BDBM50524300 (LY2606368 | Prexasertib | US11564920, Example Prex...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
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NUAK family SNF1-like kinase 1 (Human)	BDBM50524300 (LY2606368 | Prexasertib | US11564920, Example Prex...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	64	n/a	n/a	n/a	n/a	n/a	n/a
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Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM50524300 (LY2606368 | Prexasertib | US11564920, Example Prex...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Ribosomal protein S6 kinase beta-1 (Human)	BDBM50524300 (LY2606368 | Prexasertib | US11564920, Example Prex...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	382	n/a	n/a	n/a	n/a	n/a	n/a
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Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM50524300 (LY2606368 | Prexasertib | US11564920, Example Prex...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	386	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Lck (Human)	BDBM50524300 (LY2606368 | Prexasertib | US11564920, Example Prex...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Chk1 (Human)	BDBM50524300 (LY2606368 | Prexasertib | US11564920, Example Prex...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.540	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Blk (Human)	BDBM50524300 (LY2606368 | Prexasertib | US11564920, Example Prex...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.41E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Cyclin-dependent kinase 1 (Human)	BDBM50524300 (LY2606368 | Prexasertib | US11564920, Example Prex...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase pim-3 (Human)	BDBM50524300 (LY2606368 | Prexasertib | US11564920, Example Prex...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Human)	BDBM50524300 (LY2606368 | Prexasertib | US11564920, Example Prex...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Chk2 (Human)	BDBM50524300 (LY2606368 | Prexasertib | US11564920, Example Prex...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Chk1 (Human)	BDBM50524300 (LY2606368 | Prexasertib | US11564920, Example Prex...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.560	n/a	n/a	n/a	n/a	n/a	n/a
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5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1 (Human)	BDBM50524300 (LY2606368 | Prexasertib | US11564920, Example Prex...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	102	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Lyn (Human)	BDBM50524300 (LY2606368 | Prexasertib | US11564920, Example Prex...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Chk1 (Human)	BDBM50524300 (LY2606368 | Prexasertib | US11564920, Example Prex...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.540	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Human)	BDBM50524300 (LY2606368 | Prexasertib | US11564920, Example Prex...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair