BDBM50528817 CHEMBL4462530::US10717746, Example 14::US20230416221, Compound AZD4573

SMILES: CC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(-c2cnn3CC(C)(C)Cc23)c(Cl)cn1

InChI Key: InChIKey=AVIWDYSJSPOOAR-UHFFFAOYSA-N

Data: 29 IC50  2 Kd  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 32 hits for monomerid = 50528817   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Casein kinase I isoform gamma-2 (Human)	BDBM50528817 (CHEMBL4462530 | US10717746, Example 14 | US2023041...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	6.66E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 9 (Human)	BDBM50528817 (CHEMBL4462530 | US10717746, Example 14 | US2023041...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-T1/Cyclin-dependent kinase 9 (Human)	BDBM50528817 (CHEMBL4462530 | US10717746, Example 14 | US2023041...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 7 (Human)	BDBM50528817 (CHEMBL4462530 | US10717746, Example 14 | US2023041...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4/6 (Human)	BDBM50528817 (CHEMBL4462530 | US10717746, Example 14 | US2023041...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2 (Human)	BDBM50528817 (CHEMBL4462530 | US10717746, Example 14 | US2023041...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 1 (Human)	BDBM50528817 (CHEMBL4462530 | US10717746, Example 14 | US2023041...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	370	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-T1/Cyclin-dependent kinase 9 (Human)	BDBM50528817 (CHEMBL4462530 | US10717746, Example 14 | US2023041...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-T1/Cyclin-dependent kinase 9 (Human)	BDBM50528817 (CHEMBL4462530 | US10717746, Example 14 | US2023041...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 9 (Human)	BDBM50528817 (CHEMBL4462530 | US10717746, Example 14 | US2023041...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	14	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 9 (Human)	BDBM50528817 (CHEMBL4462530 | US10717746, Example 14 | US2023041...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-T1/Cyclin-dependent kinase 9 (Human)	BDBM50528817 (CHEMBL4462530 | US10717746, Example 14 | US2023041...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 8 (Human)	BDBM50528817 (CHEMBL4462530 | US10717746, Example 14 | US2023041...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Human)	BDBM50528817 (CHEMBL4462530 | US10717746, Example 14 | US2023041...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	247	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 alpha (Human)	BDBM50528817 (CHEMBL4462530 | US10717746, Example 14 | US2023041...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	187	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Dual specificity tyrosine-phosphorylation-regulated kinase 2 (Human)	BDBM50528817 (CHEMBL4462530 | US10717746, Example 14 | US2023041...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8.62E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 9 (Human)	BDBM50528817 (CHEMBL4462530 | US10717746, Example 14 | US2023041...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 (Human)	BDBM50528817 (CHEMBL4462530 | US10717746, Example 14 | US2023041...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	117	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 (Human)	BDBM50528817 (CHEMBL4462530 | US10717746, Example 14 | US2023041...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	52	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 3 (Human)	BDBM50528817 (CHEMBL4462530 | US10717746, Example 14 | US2023041...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4 (Human)	BDBM50528817 (CHEMBL4462530 | US10717746, Example 14 | US2023041...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	499	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 (Human)	BDBM50528817 (CHEMBL4462530 | US10717746, Example 14 | US2023041...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.27E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 6 (Human)	BDBM50528817 (CHEMBL4462530 | US10717746, Example 14 | US2023041...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	363	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Human)	BDBM50528817 (CHEMBL4462530 | US10717746, Example 14 | US2023041...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.37E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 12 (Human)	BDBM50528817 (CHEMBL4462530 | US10717746, Example 14 | US2023041...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8.07E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-T1/Cyclin-dependent kinase 9 (Human)	BDBM50528817 (CHEMBL4462530 | US10717746, Example 14 | US2023041...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	0.0894	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-T1/Cyclin-dependent kinase 9 (Human)	BDBM50528817 (CHEMBL4462530 | US10717746, Example 14 | US2023041...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	711	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Casein kinase I isoform gamma-1 (Human)	BDBM50528817 (CHEMBL4462530 | US10717746, Example 14 | US2023041...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.52E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 9 (Human)	BDBM50528817 (CHEMBL4462530 | US10717746, Example 14 | US2023041...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 9 (Human)	BDBM50528817 (CHEMBL4462530 | US10717746, Example 14 | US2023041...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-T1/Cyclin-dependent kinase 9 (Human)	BDBM50528817 (CHEMBL4462530 | US10717746, Example 14 | US2023041...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 9 (Human)	BDBM50528817 (CHEMBL4462530 | US10717746, Example 14 | US2023041...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair