BDBM50529421 CHEMBL4530872
SMILES FC(F)(F)c1ccccc1CN1CCN(CC1=O)c1cn[nH]c(=O)c1Cl
InChI Key InChIKey=MITRKIWBJVJRAM-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 9 hits for monomerid = 50529421
TargetShort transient receptor potential channel 6(Homo sapiens (Human))
Goldfinch Bio
Curated by ChEMBL
Goldfinch Bio
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of OAG-activated human TRPC6 channel expressed in HEK293 cells by Q-patch clamp assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Goldfinch Bio
Curated by ChEMBL
Goldfinch Bio
Curated by ChEMBL
Affinity DataIC50: 8.70E+3nMAssay Description:Inhibition of human ERG stably expressed in HEK293 cells measured at holding potential of -90 mV by manual patch clamp assayMore data for this Ligand-Target Pair
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Goldfinch Bio
Curated by ChEMBL
Goldfinch Bio
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human Nav1.5 stably expressed in CHO cells measured at holding potential of -80 mV by manual patch clamp assayMore data for this Ligand-Target Pair
Affinity DataIC50: 180nMAssay Description:Inhibition of rosiglitazone-activated rat TRPC5 channel expressed in HEK293 cells assessed as reduction in Ca2+ current measured at +80 mV with holdi...More data for this Ligand-Target Pair
TargetShort transient receptor potential channel 5(Homo sapiens (Human))
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of human TRPC5 channel expressed in HEK293 cells assessed as inhibition of EA-evoked channel current measured at +80 mV by whole-cell volt...More data for this Ligand-Target Pair
TargetShort transient receptor potential channel 5(Homo sapiens (Human))
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 180nMAssay Description:Inhibition of rosiglitazone-activated human TRPC5 channel expressed in HEK293 cells assessed as reduction in Ca2+ current measured at +80 mV with hol...More data for this Ligand-Target Pair
Affinity DataIC50: 290nMAssay Description:Inhibition of Englerin-activated human TRPC4 channel expressed in HEK293 cells by Q-patch clamp assayMore data for this Ligand-Target Pair
TargetShort transient receptor potential channel 5(Homo sapiens (Human))
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 211nMAssay Description:Inhibition of TRPC5 channel (unknown origin) expressed in HEK293 cells assessed as inhibition of EA-evoked Ca2+ entry by measuring reduction in intra...More data for this Ligand-Target Pair
TargetShort transient receptor potential channel 5(Homo sapiens (Human))
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 280nMAssay Description:Inhibition of human TRPC5 channel expressed in HEK293 cells assessed as decrease in current amplitude treated for 3 mins measured between +80 mV and ...More data for this Ligand-Target Pair