BDBM50537742 CHEMBL4634634::US11179389, Compound 1-14

SMILES: C[C@@H]1C[C@H]1C(=O)N1CCN(C[C@H]1C)c1cnc(C#N)c(n1)-c1cnn(C)c1

InChI Key: InChIKey=GXEXIUKEWXZCEF-UHFFFAOYSA-N

Data: 274 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 275 hits for monomerid = 50537742   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [14-604] (Human)	BDBM50537742 (CHEMBL4634634 | US11179389, Compound 1-14) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	8.90	n/a	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase D2 (Human)	BDBM50537742 (CHEMBL4634634 | US11179389, Compound 1-14) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Ribosomal protein S6 kinase alpha-6 (Human)	BDBM50537742 (CHEMBL4634634 | US11179389, Compound 1-14) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Platelet-derived growth factor receptor alpha (Human)	BDBM50537742 (CHEMBL4634634 | US11179389, Compound 1-14) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase 3 (Human)	BDBM50537742 (CHEMBL4634634 | US11179389, Compound 1-14) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Ribosomal protein S6 kinase alpha-1 (Human)	BDBM50537742 (CHEMBL4634634 | US11179389, Compound 1-14) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Platelet-derived growth factor receptor alpha (Human)	BDBM50537742 (CHEMBL4634634 | US11179389, Compound 1-14) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase pim-2 (Human)	BDBM50537742 (CHEMBL4634634 | US11179389, Compound 1-14) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Phosphatidylinositol 4-kinase alpha (Human)	BDBM50537742 (CHEMBL4634634 | US11179389, Compound 1-14) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase Sgk3 (Human)	BDBM50537742 (CHEMBL4634634 | US11179389, Compound 1-14) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ABL1 (Human)	BDBM50537742 (CHEMBL4634634 | US11179389, Compound 1-14) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Protein kinase C eta type (Human)	BDBM50537742 (CHEMBL4634634 | US11179389, Compound 1-14) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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SRC kinase signaling inhibitor 1 (Human)	BDBM50537742 (CHEMBL4634634 | US11179389, Compound 1-14) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Phosphatidylinositol 4-kinase beta (Human)	BDBM50537742 (CHEMBL4634634 | US11179389, Compound 1-14) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase PAK 2 (Human)	BDBM50537742 (CHEMBL4634634 | US11179389, Compound 1-14) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase TXK (Human)	BDBM50537742 (CHEMBL4634634 | US11179389, Compound 1-14) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Protein kinase C delta type (Human)	BDBM50537742 (CHEMBL4634634 | US11179389, Compound 1-14) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Human)	BDBM50537742 (CHEMBL4634634 | US11179389, Compound 1-14) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
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High affinity nerve growth factor receptor (Human)	BDBM50537742 (CHEMBL4634634 | US11179389, Compound 1-14) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Platelet-derived growth factor receptor beta (Human)	BDBM50537742 (CHEMBL4634634 | US11179389, Compound 1-14) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase Nek2 (Human)	BDBM50537742 (CHEMBL4634634 | US11179389, Compound 1-14) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Focal adhesion kinase 1 (Human)	BDBM50537742 (CHEMBL4634634 | US11179389, Compound 1-14) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Human)	BDBM50537742 (CHEMBL4634634 | US11179389, Compound 1-14) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	65	n/a	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM50537742 (CHEMBL4634634 | US11179389, Compound 1-14) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Voltage-dependent L-type calcium channel subunit alpha-1C (Human)	BDBM50537742 (CHEMBL4634634 | US11179389, Compound 1-14) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Sodium channel protein type 5 subunit alpha (Human)	BDBM50537742 (CHEMBL4634634 | US11179389, Compound 1-14) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Nuclear receptor subfamily 1 group I member 2 (Human)	BDBM50537742 (CHEMBL4634634 | US11179389, Compound 1-14) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a
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Cytochrome P450 3A4 (Human)	BDBM50537742 (CHEMBL4634634 | US11179389, Compound 1-14) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 2C9 (Human)	BDBM50537742 (CHEMBL4634634 | US11179389, Compound 1-14) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cytochrome P450 2D6 (Human)	BDBM50537742 (CHEMBL4634634 | US11179389, Compound 1-14) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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cAMP-dependent protein kinase catalytic subunit alpha (Human)	BDBM50537742 (CHEMBL4634634 | US11179389, Compound 1-14) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Human)	BDBM50537742 (CHEMBL4634634 | US11179389, Compound 1-14) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	884	n/a	n/a	n/a	n/a	n/a	n/a
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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Human)	BDBM50537742 (CHEMBL4634634 | US11179389, Compound 1-14) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	945	n/a	n/a	n/a	n/a	n/a	n/a
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Mitogen-activated protein kinase 10 (Human)	BDBM50537742 (CHEMBL4634634 | US11179389, Compound 1-14) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.37E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase JAK3 (Human)	BDBM50537742 (CHEMBL4634634 | US11179389, Compound 1-14) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.37E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Sphingosine kinase 1 (Human)	BDBM50537742 (CHEMBL4634634 | US11179389, Compound 1-14) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.38E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Aurora kinase A (Human)	BDBM50537742 (CHEMBL4634634 | US11179389, Compound 1-14) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
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MAP kinase-activated protein kinase 3 (Human)	BDBM50537742 (CHEMBL4634634 | US11179389, Compound 1-14) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.35E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Fgr (Human)	BDBM50537742 (CHEMBL4634634 | US11179389, Compound 1-14) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.54E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Misshapen-like kinase 1 (Human)	BDBM50537742 (CHEMBL4634634 | US11179389, Compound 1-14) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.56E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Glycogen synthase kinase-3 alpha (Human)	BDBM50537742 (CHEMBL4634634 | US11179389, Compound 1-14) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.61E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Mitogen-activated protein kinase kinase kinase kinase 4 (Human)	BDBM50537742 (CHEMBL4634634 | US11179389, Compound 1-14) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.63E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Glycogen synthase kinase-3 beta (Human)	BDBM50537742 (CHEMBL4634634 | US11179389, Compound 1-14) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.81E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Ribosomal protein S6 kinase alpha-3 (Human)	BDBM50537742 (CHEMBL4634634 | US11179389, Compound 1-14) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.91E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Mitogen-activated protein kinase kinase kinase kinase 5 (Human)	BDBM50537742 (CHEMBL4634634 | US11179389, Compound 1-14) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.04E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Ephrin type-A receptor 1 (Human)	BDBM50537742 (CHEMBL4634634 | US11179389, Compound 1-14) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
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G protein-coupled receptor kinase 4 (Human)	BDBM50537742 (CHEMBL4634634 | US11179389, Compound 1-14) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.47E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Yes (Human)	BDBM50537742 (CHEMBL4634634 | US11179389, Compound 1-14) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Vascular endothelial growth factor receptor 2 (Human)	BDBM50537742 (CHEMBL4634634 | US11179389, Compound 1-14) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.76E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase HCK (Human)	BDBM50537742 (CHEMBL4634634 | US11179389, Compound 1-14) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.76E+4	n/a	n/a	n/a	n/a	n/a	n/a
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