BDBM50539763 Adagrasib::Mrtx-849::Mrtx849

SMILES: CN1CCC[C@H]1COc1nc2CN(CCc2c(n1)N1CCN([C@@H](CC#N)C1)C(=O)C(F)=C)c1cccc2cccc(Cl)c12

InChI Key: InChIKey=PEMUGDMSUDYLHU-UHFFFAOYSA-N

Data: 2 KI  6 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50539763   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
GTPase KRas (Human)	BDBM50539763 (Adagrasib | Mrtx-849 | Mrtx849) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
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GTPase KRas (Human)	BDBM50539763 (Adagrasib | Mrtx-849 | Mrtx849) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
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GTPase KRas (Human)	BDBM50539763 (Adagrasib | Mrtx-849 | Mrtx849) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
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CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 (Human)	BDBM50539763 (Adagrasib | Mrtx-849 | Mrtx849) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
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GTPase KRas (Human)	BDBM50539763 (Adagrasib | Mrtx-849 | Mrtx849) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	10	n/a	n/a	n/a	n/a
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GTPase KRas (Human)	BDBM50539763 (Adagrasib | Mrtx-849 | Mrtx849) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
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Platelet-derived growth factor receptor alpha/beta (Mouse)	BDBM50539763 (Adagrasib | Mrtx-849 | Mrtx849) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
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GTPase KRas (Human)	BDBM50539763 (Adagrasib | Mrtx-849 | Mrtx849) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
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GTPase KRas (Human)	BDBM50539763 (Adagrasib | Mrtx-849 | Mrtx849) Show SMILES Show InChI	GoogleScholar	UniChem		3.70E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
GTPase KRas (Human)	BDBM50539763 (Adagrasib | Mrtx-849 | Mrtx849) Show SMILES Show InChI	GoogleScholar	UniChem		3.70E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair