BDBM50549516 CHEMBL4764938

SMILES CC(=O)N[C@@H]1CCC[C@@H](C1)C(=O)Nc1cc(-c2nnn3ccccc23)c(Cl)cn1

InChI Key InChIKey=KEMVWIFBROQSEE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50549516   

TargetCyclin-dependent kinase 9(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50549516(CHEMBL4764938)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of CDK9 in human MCF7 cells assessed as reduction in RNA Polymerase 2 CTD phosphorylation at Ser2 residues measured after 6 hrs by immunof...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50549516(CHEMBL4764938)
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibition of recombinant full length human N-terminal GST-fused CDK9 (1 to 372 residues)/His-tagged CyclinT1 (1 to 726 residues) expressed in baculo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed