BDBM50555341 CHEMBL4783788::US11306078, Example 2.073

SMILES CC(C)N1CC[C@H](NC(=O)c2cc(on2)-c2ccc(F)cc2F)[C@H](C1)C(=O)NC1(CC1)c1ncccn1

InChI Key InChIKey=NBOHWLCEOZCLMI-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50555341   

TargetAtypical chemokine receptor 3(Human)
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM50555341(CHEMBL4783788 | US11306078, Example 2.073)
Affinity DataIC50: 20nMAssay Description:Tango CXCR7-bla U2OS cells are detached from culture dishes with 0.05% trypsin-EDTA and collected in growing medium (McCoy's 5A 90% (v/v), dialyz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2022
Entry Details
US Patent

TargetAtypical chemokine receptor 3(Human)
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM50555341(CHEMBL4783788 | US11306078, Example 2.073)
Affinity DataIC50: 21nMAssay Description:Antagonist activity at CXCR7 (unknown origin) expressed in human U2OS cells co-expressing beta-arrestin assessed as reduction in CXCL12-alpha induced...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Idorsia Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50555341(CHEMBL4783788 | US11306078, Example 2.073)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells at -40 mV holding potential by Q-patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed