BDBM50559315 CHEMBL4800682

SMILES Cc1nc(NC(=O)N2CCC[C@H]2C(O)=O)sc1-c1ccnc(c1)C(C)(C)C(F)(F)F

InChI Key InChIKey=ZFOZUOSYVNYMPT-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50559315   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Lupin

Curated by ChEMBL

LigandBDBM50559315(CHEMBL4800682)Copy SMILESCopy InChI

Affinity DataIC50: 13nMAssay Description:Inhibition of PI3Kalpha in human MDA-MB-453 cells assessed as reduction in phosphorylation of AKT at 473 measured after 1 hr by alpha screen assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/27/2022
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Lupin

Curated by ChEMBL

LigandBDBM50559315(CHEMBL4800682)Copy SMILESCopy InChI

Affinity DataIC50: 29nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate in presence of ATP measured after 45 mins by HTRF assay relative to controlMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
3/27/2022
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL