BDBM50592470 CHEMBL5189795::US20240002365, Compound CTx-0294885

SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc(cc2)N2CCNCC2)ncc1Cl

InChI Key InChIKey=FCLOIQHNUARDSR-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50592470   

TargetFibroblast growth factor receptor 1(Human)
Beta Pharma

US Patent
LigandPNGBDBM50592470(CHEMBL5189795 | US20240002365, Compound CTx-029488...)
Affinity DataIC50: 35nMAssay Description:The reaction procedure was conducted as follows:1) Prepare substrate in freshly prepared Reaction Buffer.2) MnCl2 (2 mM) was added as a co-factor lis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2024
Entry Details
US Patent

TargetMitogen-activated protein kinase 8(Human)
Modern University for Technology and Information (MTI)

Curated by ChEMBL
LigandPNGBDBM50592470(CHEMBL5189795 | US20240002365, Compound CTx-029488...)
Affinity DataIC50: 280nMAssay Description:Inhibition of JNK1 (unknown origin) expressed in HEK293 cells assessed as target engagement incubated for 1 hr by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase 10(Human)
University of Sharjah

Curated by ChEMBL
LigandPNGBDBM50592470(CHEMBL5189795 | US20240002365, Compound CTx-029488...)
Affinity DataIC50: 370nMAssay Description:Inhibition of JNK3 in human HEK293 cells transfected with JNK3-NanoLuc fusion vector measured after 1 hr by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed