BDBM50595124 CHEBI:49960::Caprelsa::GNF-PF-2188::NSC-744325::NSC-760766::VANDETANIB::Vandetanib::ZD-64::ZD-6474::ZD6474::Zactima
SMILES COc1cc2c(cc1OCC1CCN(C)CC1)[nH]cn\c2=N/c1ccc(Br)cc1F
InChI Key InChIKey=UHTHHESEBZOYNR-UHFFFAOYSA-N
Data 23 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 50 hits for monomerid = 50595124
TargetVascular endothelial growth factor receptor 2(Human)
University of Arkansas For Medical Sciences
Curated by ChEMBL
University of Arkansas For Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 3(Human)
University of Arkansas For Medical Sciences
Curated by ChEMBL
University of Arkansas For Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 0.110nMAssay Description:Inhibition of VEGFR3 (unknown origin)More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Arkansas For Medical Sciences
Curated by ChEMBL
University of Arkansas For Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 0.130nMAssay Description:Inhibition of RET (unknown origin)More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Human)
University of Arkansas For Medical Sciences
Curated by ChEMBL
University of Arkansas For Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 0.5nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Complutense University of Madrid
Curated by ChEMBL
Complutense University of Madrid
Curated by ChEMBL
Affinity DataIC50: 0.790nMAssay Description:Inhibition of SRC (unknown origin)More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 1(Human)
University of Arkansas For Medical Sciences
Curated by ChEMBL
University of Arkansas For Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of VEGFR1 (unknown origin)More data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor beta(Human)
University of Arkansas For Medical Sciences
Curated by ChEMBL
University of Arkansas For Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of PDGFRbeta (unknown origin)More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Human)
University of Arkansas For Medical Sciences
Curated by ChEMBL
University of Arkansas For Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of FGFR1 (unknown origin)More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
University of Arkansas For Medical Sciences
Curated by ChEMBL
University of Arkansas For Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant VEGFR2 (unknown origin) incubated for 120 mins by Perkin Elmer electrophoretic mobility shift platform methodMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Arkansas For Medical Sciences
Curated by ChEMBL
University of Arkansas For Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of recombinant RET M918T (unknown origin) incubated for 120 mins by Perkin Elmer electrophoretic mobility shift platform methodMore data for this Ligand-Target Pair
TargetCoiled-coil domain-containing protein 6(Human)
University of Arkansas For Medical Sciences
Curated by ChEMBL
University of Arkansas For Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of recombinant CCDC6-RET (unknown origin) incubated for 120 mins by Perkin Elmer electrophoretic mobility shift platform methodMore data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Human)
University of Arkansas For Medical Sciences
Curated by ChEMBL
University of Arkansas For Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of c-kit (unknown origin)More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Human)
University of Arkansas For Medical Sciences
Curated by ChEMBL
University of Arkansas For Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Arkansas For Medical Sciences
Curated by ChEMBL
University of Arkansas For Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of RET (unknown origin)More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
University of Arkansas For Medical Sciences
Curated by ChEMBL
University of Arkansas For Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of VEGFR-2 (unknown origin)More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
University of Arkansas For Medical Sciences
Curated by ChEMBL
University of Arkansas For Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibition of VEGFR-2 (unknown origin) in presence of ATP at 2 uM by enzymatic assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
University of Arkansas For Medical Sciences
Curated by ChEMBL
University of Arkansas For Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibition of VEGFR2 (unknown origin) by ELISAMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
University of Arkansas For Medical Sciences
Curated by ChEMBL
University of Arkansas For Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assayMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Arkansas For Medical Sciences
Curated by ChEMBL
University of Arkansas For Medical Sciences
Curated by ChEMBL
TargetVascular endothelial growth factor receptor 2(Human)
University of Arkansas For Medical Sciences
Curated by ChEMBL
University of Arkansas For Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 54nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Arkansas For Medical Sciences
Curated by ChEMBL
University of Arkansas For Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 60nMAssay Description:Inhibition of RET (unknown origin)More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Arkansas For Medical Sciences
Curated by ChEMBL
University of Arkansas For Medical Sciences
Curated by ChEMBL
TargetVascular endothelial growth factor receptor 2(Human)
University of Arkansas For Medical Sciences
Curated by ChEMBL
University of Arkansas For Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 94nMAssay Description:Inhibition of recombinant VEGFR2 (unknown origin) by kinase glo detection reagent based assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
University of Arkansas For Medical Sciences
Curated by ChEMBL
University of Arkansas For Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 94nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Arkansas For Medical Sciences
Curated by ChEMBL
University of Arkansas For Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of RET (unknown origin) by kinome scan assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 3(Human)
University of Arkansas For Medical Sciences
Curated by ChEMBL
University of Arkansas For Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 3(Human)
University of Arkansas For Medical Sciences
Curated by ChEMBL
University of Arkansas For Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Inhibition of VEGFR3 (unknown origin) by ELISAMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Arkansas For Medical Sciences
Curated by ChEMBL
University of Arkansas For Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 128nMAssay Description:Inhibition of human recombinant GST tagged-RET using IRF-1Rtide as substrate in presence of ATP by ADP-Glo luminescence kinase assayMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Arkansas For Medical Sciences
Curated by ChEMBL
University of Arkansas For Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 130nMAssay Description:Inhibition of wildtype RET (unknown origin) incubated for 120 mins by Perkin Elmer electrophoretic mobility shift platform methodMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Arkansas For Medical Sciences
Curated by ChEMBL
University of Arkansas For Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 130nMAssay Description:Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assayMore data for this Ligand-Target Pair
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Federal University of Parana
Curated by ChEMBL
Federal University of Parana
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Inhibition of ABCG2 (unknown origin) expressed in human S1M180 cells assessed as intracellular accumulation of rhodamine 123 using rhodamine 123 as s...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Human)
University of Arkansas For Medical Sciences
Curated by ChEMBL
University of Arkansas For Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 369nMAssay Description:Inhibition of EGFR L858R/T790M/C797S triple mutant (unknown origin)More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Human)
University of Arkansas For Medical Sciences
Curated by ChEMBL
University of Arkansas For Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 369nMAssay Description:Inhibition of EGFR L858R/T790M/C797S triple mutant (unknown origin) expressed in Bac-to-Bac baculovirus expression system measured after 2 hrs by ELI...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Human)
University of Arkansas For Medical Sciences
Curated by ChEMBL
University of Arkansas For Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 500nMAssay Description:Inhibition of HER1 (unknown origin) by ELISAMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Human)
University of Arkansas For Medical Sciences
Curated by ChEMBL
University of Arkansas For Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 500nMAssay Description:Inhibition of EGFR (unknown origin) in presence of ATP by enzymatic assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Human)
University of Arkansas For Medical Sciences
Curated by ChEMBL
University of Arkansas For Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 500nMAssay Description:Negative allosteric modulation of rat mGlu3 receptor assessed as calcium mobilization by cell based fluorescence assayMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Arkansas For Medical Sciences
Curated by ChEMBL
University of Arkansas For Medical Sciences
Curated by ChEMBL
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Arkansas For Medical Sciences
Curated by ChEMBL
University of Arkansas For Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of FLT3 (unknown origin) by bioluminescent ADP-Glo assayMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor beta(Human)
University of Arkansas For Medical Sciences
Curated by ChEMBL
University of Arkansas For Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human PDGFRbeta using poly (Glu, Tyr)4:1 as substrate measured after 60 mins by ELISAMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 1(Human)
University of Arkansas For Medical Sciences
Curated by ChEMBL
University of Arkansas For Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of VEGFR-1 (unknown origin) in presence of ATP by enzymatic assayMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Arkansas For Medical Sciences
Curated by ChEMBL
University of Arkansas For Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of recombinant RET V804L (unknown origin) incubated for 120 mins by Perkin Elmer electrophoretic mobility shift platform methodMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Arkansas For Medical Sciences
Curated by ChEMBL
University of Arkansas For Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 5.13E+3nMAssay Description:Inhibition of RET in bortezomib Resistant human RPMI-8226 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous one...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HDAC (unknown origin)More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Arkansas For Medical Sciences
Curated by ChEMBL
University of Arkansas For Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of RET in human bortezomib-resistant ANBL6 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous one sol...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Arkansas For Medical Sciences
Curated by ChEMBL
University of Arkansas For Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of RET in human U-266 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous one solution cell proliferat...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Arkansas For Medical Sciences
Curated by ChEMBL
University of Arkansas For Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of RET in Melphalan Resistant human RPMI-8226 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous one ...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Arkansas For Medical Sciences
Curated by ChEMBL
University of Arkansas For Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of RET in human RPMI-8226 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous one solution cell prolif...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Human)
University of Arkansas For Medical Sciences
Curated by ChEMBL
University of Arkansas For Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EGFR in human RPMI-8226 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous one solution cell proli...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Arkansas For Medical Sciences
Curated by ChEMBL
University of Arkansas For Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of RET in human ANBL-6 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous one solution cell prolifera...More data for this Ligand-Target Pair