BDBM50613861 CHEMBL5288888

SMILES Fc1c(Cl)cccc1Nc1ncnc2cc(O[C@H]3CCOC3)c(OC3CCN(CC3)C(=O)C=C)cc12

InChI Key InChIKey=WAYSVGLDKMEZLH-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50613861   

TargetEpidermal growth factor receptor(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50613861(CHEMBL5288888)
Affinity DataIC50: 0.0270nMAssay Description:Inhibition of EGFR D770-N771 ins NPG mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50613861(CHEMBL5288888)
Affinity DataIC50: 0.112nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50613861(CHEMBL5288888)
Affinity DataIC50: 0.116nMAssay Description:Inhibition of EGFR A763-Y764 ins FQEA mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50613861(CHEMBL5288888)
Affinity DataIC50: 0.406nMAssay Description:Inhibition of wild type EGFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50613861(CHEMBL5288888)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of HER2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50613861(CHEMBL5288888)
Affinity DataIC50: 818nMAssay Description:Inhibition of EGFR L858R/T790M/C797S mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM50613861(CHEMBL5288888)
Affinity DataIC50: 1.50E+4nMAssay Description:Binding affinity to human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed