BDBM50616137 CHEMBL5434933

SMILES c1ccc(c(c1)C(F)(F)F)Nc2cccc3c2CN(C3)C#N

InChI Key InChIKey=CLAZWTDTANKWLV-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50616137   

TargetTranscriptional enhancer factor TEF-1(Human)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50616137(CHEMBL5434933)
Affinity DataIC50: 1.30E+3nMAssay Description:Displacement of FAM- labeled YAP1 peptide (60 to 99 residues) from human TEAD1 (209 to 426 residues) expressed in Escherichia coli BL21 (DE3) cells i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTranscriptional enhancer factor TEF-4(Human)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50616137(CHEMBL5434933)
Affinity DataIC50: 2.10E+3nMAssay Description:Displacement of FAM- labeled YAP1 peptide (60 to 99 residues) from human TEAD2 (217 to 447 residues) expressed in Escherichia coli BL21 (DE3) cells i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTranscriptional enhancer factor TEF-3(Human)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50616137(CHEMBL5434933)
Affinity DataIC50: 5.40E+3nMAssay Description:Displacement of FAM- labeled YAP1 peptide (60 to 99 residues) from human TEAD4 (217 to 434 residues) expressed in Escherichia coli BL21 (DE3) cells i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetTranscriptional enhancer factor TEF-3(Human)
Indiana University

Curated by ChEMBL
LigandPNGBDBM50616137(CHEMBL5434933)
Affinity DataIC50: 1.05E+4nMAssay Description:Inhibition of TEAD4 (unknown origin) transfected in human HEK293 cells co-transfected with renilla plasmid assessed as inhibition of transcriptional ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed