BDBM5106 1,2,4-Oxadiazole Analogue 15c::4-[(2S)-2-{[(1S)-2-hydroxy-1-[3-(naphthalen-2-ylmethyl)-1,2,4-oxadiazol-5-yl]ethyl]carbamoyl}-2-(1-phenylacetamido)ethyl]phenoxyphosphonic acid

SMILES OC[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(=O)Cc1ccccc1)c1nc(Cc2ccc3ccccc3c2)no1

InChI Key InChIKey=RRNYTUGEKKWGTI-NSOVKSMOSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 5106   

TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Ariad Pharmaceuticals

LigandPNGBDBM5106(1,2,4-Oxadiazole Analogue 15c | 4-[(2S)-2-{[(1S)-2...)
Affinity DataIC50:  1.00E+3nMAssay Description:Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Ariad Pharmaceuticals

LigandPNGBDBM5106(1,2,4-Oxadiazole Analogue 15c | 4-[(2S)-2-{[(1S)-2...)
Affinity DataIC50: >5.00E+5nMAssay Description:Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth factor receptor-bound protein 2(Homo sapiens (Human))
Ariad Pharmaceuticals

LigandPNGBDBM5106(1,2,4-Oxadiazole Analogue 15c | 4-[(2S)-2-{[(1S)-2...)
Affinity DataIC50:  3.68E+5nMAssay Description:Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Ariad Pharmaceuticals

LigandPNGBDBM5106(1,2,4-Oxadiazole Analogue 15c | 4-[(2S)-2-{[(1S)-2...)
Affinity DataIC50:  6.80E+4nMAssay Description:Fluorescence polarization competitive binding assays were used to measure the IC50s of compounds binding to the different SH2 domains. The difference...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed