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BDBM5359 5-bromo-N-(pyridin-2-yl)-1,3-thiazol-2-amine::ACS Chemical Biology 3180 Compound 60::aminothiazole 19

SMILES: Brc1cnc(Nc2ccccn2)s1

InChI Key: InChIKey=WZNOXZQMWMMJMJ-UHFFFAOYSA-N

Data: 2 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 5359   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Aurora kinase A


(Homo sapiens (human))
BDBM5359
PNG
(5-bromo-N-(pyridin-2-yl)-1,3-thiazol-2-amine | ACS...)
Show SMILES Brc1cnc(Nc2ccccn2)s1
Show InChI InChI=1S/C8H6BrN3S/c9-6-5-11-8(13-6)12-7-3-1-2-4-10-7/h1-5H,(H,10,11,12)
PDB
MMDB

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PC sid
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Article
PubMed
n/an/a 2.00E+3n/an/an/an/an/an/a



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM5359
PNG
(5-bromo-N-(pyridin-2-yl)-1,3-thiazol-2-amine | ACS...)
Show SMILES Brc1cnc(Nc2ccccn2)s1
Show InChI InChI=1S/C8H6BrN3S/c9-6-5-11-8(13-6)12-7-3-1-2-4-10-7/h1-5H,(H,10,11,12)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 71n/an/an/an/a7.422



Merck Research Laboratories



Assay Description
Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...


Bioorg Med Chem Lett 14: 2941-5 (2004)


Article DOI: 10.1016/j.bmcl.2004.03.052
BindingDB Entry DOI: 10.7270/Q25H7DG7
More data for this
Ligand-Target Pair