BDBM53740 2-[(5-chloro-4-tosyl-thiazol-2-yl)amino]ethyl-dimethyl-amine::MLS000537009::N'-{5-chloro-4-[(4-methylphenyl)sulfonyl]-1,3-thiazol-2-yl}-N,N-dimethyl-1,2-ethanediamine::N-[5-chloranyl-4-(4-methylphenyl)sulfonyl-1,3-thiazol-2-yl]-N',N'-dimethyl-ethane-1,2-diamine::N-[5-chloro-4-(4-methylphenyl)sulfonyl-1,3-thiazol-2-yl]-N',N'-dimethylethane-1,2-diamine::N-[5-chloro-4-(4-methylphenyl)sulfonyl-2-thiazolyl]-N',N'-dimethylethane-1,2-diamine::SMR000143646::cid_1301648

SMILES CN(C)CCNc1nc(c(Cl)s1)S(=O)(=O)c1ccc(C)cc1

InChI Key InChIKey=FEDFHWHLGXWKBQ-UHFFFAOYSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 53740   

TargetM1 family aminopeptidase(Plasmodium falciparum (isolate FcB1 / Columbia))
Srmlsc

Curated by PubChem BioAssay
LigandPNGBDBM53740(2-[(5-chloro-4-tosyl-thiazol-2-yl)amino]ethyl-dime...)
Affinity DataIC50:  1.27E+4nMAssay Description:Southern Research Molecular Libraries Screening Center (SRMLSC) Southern Research Institute (Birmingham, Alabama) NIH Molecular Libraries Screening...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetNF-kappa-B inhibitor alpha(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM53740(2-[(5-chloro-4-tosyl-thiazol-2-yl)amino]ethyl-dime...)
Affinity DataEC50:  1.00E+4nMAssay Description:Induction of human IkappaBalpha stabilization in OCI-Ly3 cells assessed as ratio of green light emiting IkappaBalpha-fused luciferase expression to r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscription factor p65(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM53740(2-[(5-chloro-4-tosyl-thiazol-2-yl)amino]ethyl-dime...)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of TNF-alpha-stimulated human NF-kappaB p65 RelA subunit nuclear translocation in HUVECMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNF-kappa-B inhibitor alpha(Homo sapiens (Human))
Columbia University

Curated by ChEMBL
LigandPNGBDBM53740(2-[(5-chloro-4-tosyl-thiazol-2-yl)amino]ethyl-dime...)
Affinity DataEC50:  6.80E+3nMAssay Description:Induction of human IkappaBalpha stabilization in OCI-Ly3 cells by green light emiting IkappaBalpha-fused luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed