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BDBM5386 2,4-Disubstituted Pyrimidine 2j::N-(3,5-dichlorophenyl)-4-(2-phenyl-1H-imidazol-1-yl)pyrimidin-2-amine

SMILES: Clc1cc(Cl)cc(Nc2nccc(n2)-n2ccnc2-c2ccccc2)c1

InChI Key: InChIKey=PRMOKNGXXJPBMD-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 5386   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM5386
PNG
(2,4-Disubstituted Pyrimidine 2j | N-(3,5-dichlorop...)
Show SMILES Clc1cc(Cl)cc(Nc2nccc(n2)-n2ccnc2-c2ccccc2)c1
Show InChI InChI=1S/C19H13Cl2N5/c20-14-10-15(21)12-16(11-14)24-19-23-7-6-17(25-19)26-9-8-22-18(26)13-4-2-1-3-5-13/h1-12H,(H,23,24,25)
PDB
MMDB

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PC sid
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Similars

Article
PubMed
n/an/a 26n/an/an/an/a7.422



Merck Research Laboratories



Assay Description
Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...


Bioorg Med Chem Lett 13: 1673-7 (2003)


Article DOI: 10.1016/s0960-894x(03)00244-0
BindingDB Entry DOI: 10.7270/Q2X0657G
More data for this
Ligand-Target Pair