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BDBM5400 2,4-Disubstituted Pyrimidine 5b::N-(3,5-dimethylphenyl)-4-[2-(pyridin-3-yl)-1H-imidazol-1-yl]pyrimidin-2-amine

SMILES: Cc1cc(C)cc(Nc2nccc(n2)-n2ccnc2-c2cccnc2)c1

InChI Key: InChIKey=ZQFFEUAQGFFMDA-UHFFFAOYSA-N

Data: 2 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 5400   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM5400
PNG
(2,4-Disubstituted Pyrimidine 5b | N-(3,5-dimethylp...)
Show SMILES Cc1cc(C)cc(Nc2nccc(n2)-n2ccnc2-c2cccnc2)c1
Show InChI InChI=1S/C20H18N6/c1-14-10-15(2)12-17(11-14)24-20-23-7-5-18(25-20)26-9-8-22-19(26)16-4-3-6-21-13-16/h3-13H,1-2H3,(H,23,24,25)
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MMDB

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PC cid
PC sid
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Similars

Article
PubMed
n/an/a 2.39E+3n/an/an/an/an/an/a



Rheinische Friedrich-Wilhelms-Universit£t

Curated by ChEMBL


Assay Description
Antagonist activity at VEGFR2


J Med Chem 55: 2932-42 (2012)


Article DOI: 10.1021/jm201706b
BindingDB Entry DOI: 10.7270/Q2RJ4KGS
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM5400
PNG
(2,4-Disubstituted Pyrimidine 5b | N-(3,5-dimethylp...)
Show SMILES Cc1cc(C)cc(Nc2nccc(n2)-n2ccnc2-c2cccnc2)c1
Show InChI InChI=1S/C20H18N6/c1-14-10-15(2)12-17(11-14)24-20-23-7-5-18(25-20)26-9-8-22-19(26)16-4-3-6-21-13-16/h3-13H,1-2H3,(H,23,24,25)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 2.39E+3n/an/an/an/a7.422



Merck Research Laboratories



Assay Description
Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...


Bioorg Med Chem Lett 12: 3537-41 (2002)


Article DOI: 10.1016/s0960-894x(02)00827-2
BindingDB Entry DOI: 10.7270/Q2S75DHR
More data for this
Ligand-Target Pair