BDBM5444 6-Thiazolylquinazoline 6::CHEMBL453376::N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(2-{[(2-methanesulfonylethyl)amino]methyl}-1,3-thiazol-4-yl)quinazolin-4-amine

SMILES CS(=O)(=O)CCNCc1nc(cs1)-c1ccc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2c1

InChI Key InChIKey=MNNXRVSQOABRRP-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 5444   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM5444(6-Thiazolylquinazoline 6 | CHEMBL453376 | N-{3-chl...)
Affinity DataIC50:  10nMpH: 7.5 T: 2°CAssay Description:Enzymatic reactions were initiated by adding kinase to the reaction mixture containing ATP, [gamma-33P] ATP, peptide substrate and test inhibitor com...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
University Of Southern California

Curated by ChEMBL
LigandPNGBDBM5444(6-Thiazolylquinazoline 6 | CHEMBL453376 | N-{3-chl...)
Affinity DataIC50:  10nMAssay Description:Inhibition of HER2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
University Of Southern California

Curated by ChEMBL
LigandPNGBDBM5444(6-Thiazolylquinazoline 6 | CHEMBL453376 | N-{3-chl...)
Affinity DataIC50:  14nMpH: 7.5 T: 2°CAssay Description:Enzymatic reactions were initiated by adding kinase to the reaction mixture containing ATP, [gamma-33P] ATP, peptide substrate and test inhibitor com...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed