BindingDB PrimarySearch

BDBM5445 CHEMBL554::GW572016::LAPATINIB DITOSYLATE::Lapatinib::N-{3-chloro-4-[(3-fluoro-benzyl)oxy]phenyl}-6-[5-({2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine::N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(5-{[(2-methanesulfonylethyl)amino]methyl}furan-2-yl)quinazolin-4-amine::Tykerb::US10507209, Compound Lapatinib::US10822334, Compound Lapatinib::US9730934, Lapatinib ditosylate::cid_208908

SMILES: CS(=O)(=O)CCNCc1ccc(o1)-c1ccc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2c1

InChI Key: InChIKey=BCFGMOOMADDAQU-UHFFFAOYSA-N

Data: 3 KI 158 IC50 780 Kd 2 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 948 hits for monomerid = 5445
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Epidermal growth factor receptor (Human)	BDBM5445 (N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	10	n/a	n/a	n/a	n/a	7.5	23
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Receptor tyrosine-protein kinase erbB-2 (Human)	BDBM5445 (N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	9	n/a	n/a	n/a	n/a	7.5	23
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Epidermal growth factor receptor (Human)	BDBM5445 (N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	7.60	n/a	n/a	n/a	n/a	n/a	n/a
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Receptor tyrosine-protein kinase erbB-2 (Human)	BDBM5445 (N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	7.60	n/a	n/a	n/a	n/a	n/a	n/a
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Receptor tyrosine-protein kinase erbB-4 (Human)	BDBM5445 (N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	7.60	n/a	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM5445 (N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	11	n/a	n/a	n/a	n/a	7.5	23
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Receptor tyrosine-protein kinase erbB-2 (Human)	BDBM5445 (N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	9	n/a	n/a	n/a	n/a	7.5	23
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Receptor tyrosine-protein kinase erbB-4 (Human)	BDBM5445 (N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	367	n/a	n/a	n/a	n/a	7.5	23
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Epidermal growth factor receptor [G719C] (Human)	BDBM5445 (N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	0.920	n/a	n/a	n/a	7.4	25
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Epidermal growth factor receptor (Human)	BDBM5445 (N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM5445 (N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM5445 (N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM5445 (N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	3.90	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM5445 (N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	3.5	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM5445 (N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM5445 (N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	8.60	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor [1-999,L858R] (Human)	BDBM5445 (N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a	n/a
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Receptor-interacting serine/threonine-protein kinase 2 (Human)	BDBM5445 (N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	3.60E+3	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM5445 (N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	4.20	n/a	n/a	n/a	n/a	n/a
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Receptor tyrosine-protein kinase erbB-2 (Human)	BDBM5445 (N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM5445 (N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	3	n/a	n/a	n/a	n/a	7.5	n/a
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Receptor tyrosine-protein kinase erbB-2 (Human)	BDBM5445 (N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	13	n/a	n/a	n/a	n/a	7.5	n/a
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Receptor tyrosine-protein kinase erbB-4 (Human)	BDBM5445 (N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	347	n/a	n/a	n/a	n/a	7.5	n/a
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Epidermal growth factor receptor (Human)	BDBM5445 (N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
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Receptor tyrosine-protein kinase erbB-2 (Human)	BDBM5445 (N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
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Receptor tyrosine-protein kinase erbB-4 (Human)	BDBM5445 (N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
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Receptor tyrosine-protein kinase erbB-2 (Human)	BDBM5445 (N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	23.1	n/a	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM5445 (N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	3.07	n/a	n/a	n/a	n/a	n/a	n/a
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Bile salt export pump (Human)	BDBM5445 (N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	<1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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ATP-binding cassette sub-family C member 3 (Human)	BDBM5445 (N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Bile salt export pump (Human)	BDBM5445 (N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	6.49E+3	n/a	n/a	n/a	n/a	n/a	n/a
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ATP-binding cassette sub-family C member 2 (Human)	BDBM5445 (N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
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ATP-binding cassette sub-family C member 4 (Human)	BDBM5445 (N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>1.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM5445 (N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM5445 (N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
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Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 (Human)	BDBM5445 (N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Platelet-derived growth factor receptor alpha (Human)	BDBM5445 (N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM5445 (N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM5445 (N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
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Receptor tyrosine-protein kinase erbB-2 (Human)	BDBM5445 (N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	9.20	n/a	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM5445 (N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM5445 (N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM5445 (N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	225	n/a	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM5445 (N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	38	n/a	n/a	n/a	n/a	n/a	n/a
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Receptor tyrosine-protein kinase erbB-2 (Human)	BDBM5445 (N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM5445 (N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
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Receptor tyrosine-protein kinase erbB-2 (Human)	BDBM5445 (N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	42	n/a	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM5445 (N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Receptor tyrosine-protein kinase erbB-2 (Human)	BDBM5445 (N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM5445 (N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}-6-(...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
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