BDBM5446 CHEMBL553::ERLOTINIB HYDROCHLORIDE::Erlotinib::Erotinib::N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine Monohydrochloride::N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine::OSI-774::Tarceva::US10189853, erlotinib::US10507209, Compound Erlotinib::US11524945, Compound Erlotinib::US9409845, Table 1, Compound 22: erlotinib::US9730934, Erlotinib::WO2022090481, Example erlotinib::cid_176870

SMILES: COCCOc1cc2c(cc1OCCOC)ncnc2Nc3cccc(c3)C#C

InChI Key: InChIKey=AAKJLRGGTJKAMG-UHFFFAOYSA-N

Data: 23 KI  294 IC50  872 Kd  2 EC50

PDB links: 3 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1191 hits for monomerid = 5446   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Human)	BDBM5446 (Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1	n/a	n/a	n/a	n/a	7.5	23
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Receptor tyrosine-protein kinase erbB-2 (Human)	BDBM5446 (Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	760	n/a	n/a	n/a	n/a	7.5	23
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Epidermal growth factor receptor (Human)	BDBM5446 (Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
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Vascular endothelial growth factor receptor 2 (Human)	BDBM5446 (Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	125	n/a	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM5446 (Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.60	n/a	n/a	n/a	n/a	n/a	n/a
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Receptor tyrosine-protein kinase erbB-2 (Human)	BDBM5446 (Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.60	n/a	n/a	n/a	n/a	n/a	n/a
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Receptor tyrosine-protein kinase erbB-4 (Human)	BDBM5446 (Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.60	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ABL1 [T315I] (Human)	BDBM5446 (Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	190	n/a	n/a	n/a	7.4	25
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ALK tyrosine kinase receptor (Human)	BDBM5446 (Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.20E+3	n/a	n/a	n/a	7.4	25
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Aurora kinase A (Human)	BDBM5446 (Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.20E+3	n/a	n/a	n/a	7.4	25
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Aurora kinase B (Human)	BDBM5446 (Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a
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Aurora kinase C (Human)	BDBM5446 (Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	600	n/a	n/a	n/a	7.4	25
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Epithelial discoidin domain-containing receptor 1 (Human)	BDBM5446 (Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	790	n/a	n/a	n/a	7.4	25
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Epidermal growth factor receptor [G719C] (Human)	BDBM5446 (Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	0.850	n/a	n/a	n/a	7.4	25
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Ephrin type-A receptor 3 [1-975] (Human)	BDBM5446 (Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.40E+3	n/a	n/a	n/a	7.4	25
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Ephrin type-A receptor 7 (Human)	BDBM5446 (Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	440	n/a	n/a	n/a	7.4	25
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Ephrin type-A receptor 7 (Human)	BDBM5446 (Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.40E+3	n/a	n/a	n/a	7.4	25
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Vascular endothelial growth factor receptor 1 (Human)	BDBM5446 (Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	4.40E+3	n/a	n/a	n/a	7.4	25
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Receptor-type tyrosine-protein kinase FLT3 [D835H] (Human)	BDBM5446 (Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	350	n/a	n/a	n/a	7.4	25
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Receptor-type tyrosine-protein kinase FLT3 [D835Y] (Human)	BDBM5446 (Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	130	n/a	n/a	n/a	7.4	25
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Receptor-type tyrosine-protein kinase FLT3 (Human)	BDBM5446 (Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	820	n/a	n/a	n/a	7.4	25
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Receptor-type tyrosine-protein kinase FLT3 [N841I] (Human)	BDBM5446 (Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	500	n/a	n/a	n/a	7.4	25
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Vascular endothelial growth factor receptor 3 (Human)	BDBM5446 (Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.10E+3	n/a	n/a	n/a	7.4	25
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Tyrosine-protein kinase FRK (Human)	BDBM5446 (Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	2.00E+3	n/a	n/a	n/a	7.4	25
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Epidermal growth factor receptor [668-1210] (Human)	BDBM5446 (Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.60	n/a	n/a	n/a	n/a	7.5	23
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Epidermal growth factor receptor [696-1210,T790M] (Human)	BDBM5446 (Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	260	n/a	n/a	n/a	n/a	7.5	23
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Proto-oncogene tyrosine-protein kinase Src [251-533,S345C] (Chicken)	BDBM5446 (Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	990	n/a	n/a	n/a	n/a	7.5	23
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Proto-oncogene tyrosine-protein kinase Src [251-533,T338M,S345C] (Chicken)	BDBM5446 (Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.50E+4	n/a	n/a	n/a	n/a	7.5	23
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Hepatocyte growth factor receptor (Human)	BDBM5446 (Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	3.80E+3	n/a	n/a	n/a	n/a	n/a
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MAP kinase-interacting serine/threonine-protein kinase 1 (Human)	BDBM5446 (Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	690	n/a	n/a	n/a	n/a	n/a
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Platelet-derived growth factor receptor alpha (Human)	BDBM5446 (Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	n/a
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Platelet-derived growth factor receptor beta (Human)	BDBM5446 (Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a
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Proto-oncogene tyrosine-protein kinase receptor Ret [1-999,M918T] (Human)	BDBM5446 (Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a
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Proto-oncogene tyrosine-protein kinase receptor Ret [1-999,M918T] (Human)	BDBM5446 (Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	330	n/a	n/a	n/a	n/a	n/a
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STE20-like serine/threonine-protein kinase (Human)	BDBM5446 (Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase receptor Tie-1 (Human)	BDBM5446 (Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	850	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ABL1 (Human)	BDBM5446 (Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	310	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Blk (Human)	BDBM5446 (Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a
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Citron Rho-interacting kinase (Human)	BDBM5446 (Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	680	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM5446 (Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	0.670	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM5446 (Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	0.520	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM5446 (Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	0.520	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM5446 (Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	0.470	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM5446 (Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	0.350	n/a	n/a	n/a	n/a	n/a
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Epidermal growth factor receptor (Human)	BDBM5446 (Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Fgr (Human)	BDBM5446 (Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Lck (Human)	BDBM5446 (Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Lyn (Human)	BDBM5446 (Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	530	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase TNNI3K (Human)	BDBM5446 (Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	570	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ABL1 (Human)	BDBM5446 (Erlotinib | OSI-774 | N-(3-ethynylphenyl)-6,7-bis(...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	640	n/a	n/a	n/a	n/a	n/a
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