BDBM576012 US11466016, Example 147::{6-[(1R,2S,3S,5S)- 3-amino-2-fluoro-8- azabicyclo[3.2.1] octan-8-yl]- 3-[5-chloro- 3-(morpholin-4- yl)quinoxalin-6-yl] 1H-pyrazolo[3,4- b]pyrazin-5- yl}methanol

SMILES N[C@H]1C[C@@H]2CC[C@H]([C@H]1F)N2c1nc2[nH]nc(-c3ccc4ncc(nc4c3Cl)N3CCOCC3)c2nc1CO

InChI Key InChIKey=VXHGOHDEYPFCHT-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 576012   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM576012(US11466016, Example 147 | {6-[(1R,2S,3S,5S)- 3-am...)
Affinity DataIC50: 14nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2022
Entry Details
US Patent