BindingDB logo
myBDB logout

BDBM5897 1-(3-fluorophenyl)-3-[4-(1-oxo-2,3-dihydro-1H-isoindol-4-yl)phenyl]urea::CHEMBL182648::isoindolinone analog 4i

SMILES: Fc1cccc(NC(=O)Nc2ccc(cc2)-c2cccc3C(=O)NCc23)c1

InChI Key: InChIKey=ZIWRSRUJVKEMTR-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 5897   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM5897
PNG
(1-(3-fluorophenyl)-3-[4-(1-oxo-2,3-dihydro-1H-isoi...)
Show SMILES Fc1cccc(NC(=O)Nc2ccc(cc2)-c2cccc3C(=O)NCc23)c1
Show InChI InChI=1S/C21H16FN3O2/c22-14-3-1-4-16(11-14)25-21(27)24-15-9-7-13(8-10-15)17-5-2-6-18-19(17)12-23-20(18)26/h1-11H,12H2,(H,23,26)(H2,24,25,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 520n/an/an/an/a7.422



Abbott Laboratories



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase and biotinylated poly-Glu-Ala-Tyr substrate. HTRF is based on the proximity of a...


Bioorg Med Chem Lett 14: 4505-9 (2004)


Article DOI: 10.1016/j.bmcl.2004.06.041
BindingDB Entry DOI: 10.7270/Q2B27SH9
More data for this
Ligand-Target Pair