BDBM59206 Adenosine analog, 11

SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@@H]([C@@H](O)[C@H]1O)C(=O)NCCO

InChI Key InChIKey=YLPQAZPIFSHMAY-UHFFFAOYSA-N

Data  13 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 59206   

TargetAdenosine receptor A1(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 59206BDBM59206(Adenosine analog, 11)
Affinity DataKi:  12.8nMAssay Description:Displacement of 3[H]R-PIA from human A1 adenosine receptor expressed in CHO cells after 60 mins by Liquid scintillation analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 59206BDBM59206(Adenosine analog, 11)
Affinity DataKi:  12.8nMAssay Description:Binding affinity of ligand at human adenosine receptors expressed in CHO cell. More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2011
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 59206BDBM59206(Adenosine analog, 11)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]N6-R-phenylisopropyladenosine from human A1A adenosine receptor expressed in CHO cell membranes after 60 mins by scintillation pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
National Institutes of Health

LigandChemical structure of BindingDB Monomer ID 59206BDBM59206(Adenosine analog, 11)
Affinity DataKi:  41.7nM ΔG°:  -10.1kcal/molepH: 7.4 T: 2°CAssay Description:Binding affinity of ligand at WT and mutant human A2A ARs expressed in COS7 cell. More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2011
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
National Institutes of Health

LigandChemical structure of BindingDB Monomer ID 59206BDBM59206(Adenosine analog, 11)
Affinity DataKi:  505nMAssay Description:Binding affinity of ligand at human adenosine receptors expressed in CHO cell. More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2011
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
National Institutes of Health

LigandChemical structure of BindingDB Monomer ID 59206BDBM59206(Adenosine analog, 11)
Affinity DataKi:  505nMAssay Description:Displacement of 3[H]CGS21680 from human A2A adenosine receptor expressed in HEK293 cells after 60 mins by Liquid scintillation analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
National Institutes of Health

LigandChemical structure of BindingDB Monomer ID 59206BDBM59206(Adenosine analog, 11)
Affinity DataKi:  505nMAssay Description:Displacement of [3H]2-[p-(2-carboxyethyl)phenylethylamino]-5-N-ethylcarboxamidoadenosine from human A2A adenosine receptor expressed in HEK293 cell m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
National Institutes of Health

LigandChemical structure of BindingDB Monomer ID 59206BDBM59206(Adenosine analog, 11)
Affinity DataEC50:  942nMAssay Description:Binding affinity of ligand at human adenosine receptors expressed in CHO cell. More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2011
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
National Institutes of Health

LigandChemical structure of BindingDB Monomer ID 59206BDBM59206(Adenosine analog, 11)
Affinity DataKi:  2.11E+3nM ΔG°:  -7.74kcal/molepH: 7.4 T: 2°CAssay Description:Binding affinity of ligand at WT and mutant human A2A ARs expressed in COS7 cell. More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2011
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
National Institutes of Health

LigandChemical structure of BindingDB Monomer ID 59206BDBM59206(Adenosine analog, 11)
Affinity DataKi:  3.87E+3nM ΔG°:  -7.38kcal/molepH: 7.4 T: 2°CAssay Description:Binding affinity of ligand at WT and mutant human A2A ARs expressed in COS7 cell. More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2011
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
National Institutes of Health

LigandChemical structure of BindingDB Monomer ID 59206BDBM59206(Adenosine analog, 11)
Affinity DataKi:  9.45E+3nMAssay Description:Binding affinity of ligand at human adenosine receptors expressed in CHO cell. More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2011
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
National Institutes of Health

LigandChemical structure of BindingDB Monomer ID 59206BDBM59206(Adenosine analog, 11)
Affinity DataKi:  9.45E+3nMAssay Description:Displacement of [125I]I-AB-MECA from human A3 adenosine receptor expressed in CHO cells after 60 mins gamma counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
National Institutes of Health

LigandChemical structure of BindingDB Monomer ID 59206BDBM59206(Adenosine analog, 11)
Affinity DataKi:  9.45E+3nMAssay Description:Displacement of [125I]N6-(4-amino-3-iodobenzyl)adenosine-5-N-methyluronamide from human A3A adenosine receptor expressed in CHO cell membranes after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
National Institutes of Health

LigandChemical structure of BindingDB Monomer ID 59206BDBM59206(Adenosine analog, 11)
Affinity DataKi:  1.33E+4nM ΔG°:  -6.65kcal/molepH: 7.4 T: 2°CAssay Description:Binding affinity of ligand at WT and mutant human A2A ARs expressed in COS7 cell. More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/27/2011
Entry Details Article
PubMed