BDBM59227 Pyrazolopyrimidone analog, RGB-286147

SMILES: CC(C)c1nn(-c2c(Cl)cccc2Cl)c2nc(Cc3ccc(OCCO)cc3)[nH]c(=O)c12

InChI Key: InChIKey=RSQPNXBTPUXMQN-UHFFFAOYSA-N

Data: 13 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 59227   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 (Human)	BDBM59227 (Pyrazolopyrimidone analog, RGB-286147) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	48	n/a	n/a	n/a	n/a	n/a	n/a
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Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 (Human)	BDBM59227 (Pyrazolopyrimidone analog, RGB-286147) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
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Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 (Human)	BDBM59227 (Pyrazolopyrimidone analog, RGB-286147) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	839	n/a	n/a	n/a	n/a	n/a	n/a
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Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 (Human)	BDBM59227 (Pyrazolopyrimidone analog, RGB-286147) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	282	n/a	n/a	n/a	n/a	n/a	n/a
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Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 (Human)	BDBM59227 (Pyrazolopyrimidone analog, RGB-286147) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	51	n/a	n/a	n/a	n/a	n/a	n/a
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Cyclin-dependent kinase 3/G1/S-specific cyclin-E1 (Human)	BDBM59227 (Pyrazolopyrimidone analog, RGB-286147) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
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Cyclin-dependent kinase 5 (Human)	BDBM59227 (Pyrazolopyrimidone analog, RGB-286147) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
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CDK-activating kinase assembly factor MAT1 (Human)	BDBM59227 (Pyrazolopyrimidone analog, RGB-286147) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	71	n/a	n/a	n/a	n/a	n/a	n/a
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Glycogen synthase kinase-3 beta (Human)	BDBM59227 (Pyrazolopyrimidone analog, RGB-286147) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	754	n/a	n/a	n/a	n/a	n/a	n/a
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Cyclin-dependent kinase 12 (Human)	BDBM59227 (Pyrazolopyrimidone analog, RGB-286147) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	12	n/a	n/a	n/a	n/a
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Cyclin-H/Cyclin-dependent kinase 7 (Human)	BDBM59227 (Pyrazolopyrimidone analog, RGB-286147) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	71	n/a	n/a	n/a	n/a	n/a	n/a
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Cyclin-dependent kinase 6/G1/S-specific cyclin-D3 (Human)	BDBM59227 (Pyrazolopyrimidone analog, RGB-286147) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	282	n/a	n/a	n/a	n/a	n/a	n/a
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Cyclin-dependent kinase 9 (Human)	BDBM59227 (Pyrazolopyrimidone analog, RGB-286147) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
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Glycogen synthase kinase-3 beta (Human)	BDBM59227 (Pyrazolopyrimidone analog, RGB-286147) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	754	n/a	n/a	n/a	n/a	n/a	n/a
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