BDBM59227 Pyrazolopyrimidone analog, RGB-286147

SMILES CC(C)c1nn(-c2c(Cl)cccc2Cl)c2nc(Cc3ccc(OCCO)cc3)[nH]c(=O)c12

InChI Key InChIKey=RSQPNXBTPUXMQN-UHFFFAOYSA-N

Data  13 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 59227   

TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59227(Pyrazolopyrimidone analog, RGB-286147)
Affinity DataIC50:  48nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59227(Pyrazolopyrimidone analog, RGB-286147)
Affinity DataIC50:  15nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59227(Pyrazolopyrimidone analog, RGB-286147)
Affinity DataIC50:  839nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59227(Pyrazolopyrimidone analog, RGB-286147)
Affinity DataIC50:  282nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59227(Pyrazolopyrimidone analog, RGB-286147)
Affinity DataIC50:  51nMAssay Description:Inhibition of HCT116 cell proliferation after 72hr of incubation with compounds was determined by SRB Assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 3/G1/S-specific cyclin-E1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59227(Pyrazolopyrimidone analog, RGB-286147)
Affinity DataIC50:  9nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM59227(Pyrazolopyrimidone analog, RGB-286147)
Affinity DataIC50:  754nMAssay Description:Inhibition of GSK3-betaChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCDK-activating kinase assembly factor MAT1(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59227(Pyrazolopyrimidone analog, RGB-286147)
Affinity DataIC50:  71nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM59227(Pyrazolopyrimidone analog, RGB-286147)
Affinity DataIC50:  754nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM59227(Pyrazolopyrimidone analog, RGB-286147)
Affinity DataIC50:  71nMAssay Description:Inhibition of Cdk7/H/MAT1Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59227(Pyrazolopyrimidone analog, RGB-286147)
Affinity DataIC50:  282nMAssay Description:Inhibition of Cdk6/cyclin D3Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM59227(Pyrazolopyrimidone analog, RGB-286147)
Affinity DataIC50:  9nMAssay Description:Inhibition of Cdk9Checked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5(Homo sapiens (Human))
Gpc Biotech

LigandPNGBDBM59227(Pyrazolopyrimidone analog, RGB-286147)
Affinity DataIC50:  10nMAssay Description:Inhibition of in vitro kinase activity of purified CDKs.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed