BindingDB PrimarySearch

BDBM5931 BMS-387072::CHEMBL296468::N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-yl)piperidine-4-carboxamide::N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide::cid_3025986

SMILES: CC(C)(C)c1cnc(o1)CSc2cnc(s2)NC(=O)C3CCNCC3

InChI Key: InChIKey=OUSFTKFNBAZUKL-UHFFFAOYSA-N

Data: 4 KI 50 IC50 806 Kd

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 882 hits for monomerid = 5931
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 (Human)	BDBM5931 (cid_3025986 \| CHEMBL296468 \| N-(5-{[(5-tert-butyl-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	48	n/a	n/a	n/a	n/a	8.0	30
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Aurora kinase A (Human)	BDBM5931 (cid_3025986 \| CHEMBL296468 \| N-(5-{[(5-tert-butyl-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	7.40E+3	n/a	n/a	n/a	7.4	25
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Cyclin-dependent kinase 11B (Human)	BDBM5931 (cid_3025986 \| CHEMBL296468 \| N-(5-{[(5-tert-butyl-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	98	n/a	n/a	n/a	7.4	25
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Cyclin-dependent kinase 11A (Human)	BDBM5931 (cid_3025986 \| CHEMBL296468 \| N-(5-{[(5-tert-butyl-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	48	n/a	n/a	n/a	7.4	25
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Cyclin-dependent kinase 19 (Human)	BDBM5931 (cid_3025986 \| CHEMBL296468 \| N-(5-{[(5-tert-butyl-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	950	n/a	n/a	n/a	7.4	25
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Cyclin-dependent kinase 7 (Human)	BDBM5931 (cid_3025986 \| CHEMBL296468 \| N-(5-{[(5-tert-butyl-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	31	n/a	n/a	n/a	7.4	23
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Cyclin-dependent kinase 8 (Human)	BDBM5931 (cid_3025986 \| CHEMBL296468 \| N-(5-{[(5-tert-butyl-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	1.20E+3	n/a	n/a	n/a	7.4	23
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Cyclin-dependent kinase 9 (Human)	BDBM5931 (cid_3025986 \| CHEMBL296468 \| N-(5-{[(5-tert-butyl-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	76	n/a	n/a	n/a	7.4	23
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Dual specificity protein kinase CLK1 [R432A] (Human)	BDBM5931 (cid_3025986 \| CHEMBL296468 \| N-(5-{[(5-tert-butyl-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	410	n/a	n/a	n/a	7.4	23
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Dual specificity protein kinase CLK4 (Human)	BDBM5931 (cid_3025986 \| CHEMBL296468 \| N-(5-{[(5-tert-butyl-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	800	n/a	n/a	n/a	7.4	23
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Mitogen-activated protein kinase 15 (Human)	BDBM5931 (cid_3025986 \| CHEMBL296468 \| N-(5-{[(5-tert-butyl-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	120	n/a	n/a	n/a	7.4	25
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Receptor-type tyrosine-protein kinase FLT3 [D835H] (Human)	BDBM5931 (cid_3025986 \| CHEMBL296468 \| N-(5-{[(5-tert-butyl-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	7.40E+3	n/a	n/a	n/a	7.4	25
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Receptor-type tyrosine-protein kinase FLT3 [D835Y] (Human)	BDBM5931 (cid_3025986 \| CHEMBL296468 \| N-(5-{[(5-tert-butyl-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	3.00E+3	n/a	n/a	n/a	7.4	25
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Receptor-type tyrosine-protein kinase FLT3 [D835Y] (Human)	BDBM5931 (cid_3025986 \| CHEMBL296468 \| N-(5-{[(5-tert-butyl-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	5.20	n/a	n/a	n/a	7.4	25
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MAP kinase-interacting serine/threonine-protein kinase 1 (Human)	BDBM5931 (cid_3025986 \| CHEMBL296468 \| N-(5-{[(5-tert-butyl-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	3.80E+3	n/a	n/a	n/a	n/a	n/a
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Cyclin-dependent kinase 2 (Human)	BDBM5931 (cid_3025986 \| CHEMBL296468 \| N-(5-{[(5-tert-butyl-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	69	n/a	n/a	n/a	n/a	n/a
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Cyclin-dependent kinase 3 (Human)	BDBM5931 (cid_3025986 \| CHEMBL296468 \| N-(5-{[(5-tert-butyl-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	56	n/a	n/a	n/a	n/a	n/a
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Cyclin-dependent kinase 5 (Human)	BDBM5931 (cid_3025986 \| CHEMBL296468 \| N-(5-{[(5-tert-butyl-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	740	n/a	n/a	n/a	n/a	n/a
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Dual specificity protein kinase CLK2 (Human)	BDBM5931 (cid_3025986 \| CHEMBL296468 \| N-(5-{[(5-tert-butyl-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a
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Casein kinase I isoform delta (Human)	BDBM5931 (cid_3025986 \| CHEMBL296468 \| N-(5-{[(5-tert-butyl-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	n/a
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Casein kinase I isoform epsilon (Human)	BDBM5931 (cid_3025986 \| CHEMBL296468 \| N-(5-{[(5-tert-butyl-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	950	n/a	n/a	n/a	n/a	n/a
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Cyclin-G-associated kinase (Human)	BDBM5931 (cid_3025986 \| CHEMBL296468 \| N-(5-{[(5-tert-butyl-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a	n/a
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Maternal embryonic leucine zipper kinase (Human)	BDBM5931 (cid_3025986 \| CHEMBL296468 \| N-(5-{[(5-tert-butyl-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	5.60E+3	n/a	n/a	n/a	n/a	n/a
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Myosin light chain kinase 2, skeletal/cardiac muscle (Human)	BDBM5931 (cid_3025986 \| CHEMBL296468 \| N-(5-{[(5-tert-butyl-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	980	n/a	n/a	n/a	n/a	n/a
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Cyclin-dependent kinase 16 (Human)	BDBM5931 (cid_3025986 \| CHEMBL296468 \| N-(5-{[(5-tert-butyl-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	7.10	n/a	n/a	n/a	n/a	n/a
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Cyclin-dependent kinase 17 (Human)	BDBM5931 (cid_3025986 \| CHEMBL296468 \| N-(5-{[(5-tert-butyl-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a
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Cyclin-dependent kinase 18 [3-474] (Human)	BDBM5931 (cid_3025986 \| CHEMBL296468 \| N-(5-{[(5-tert-butyl-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	44	n/a	n/a	n/a	n/a	n/a
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Cyclin-dependent kinase 14 (Human)	BDBM5931 (cid_3025986 \| CHEMBL296468 \| N-(5-{[(5-tert-butyl-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	690	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase D1 (Human)	BDBM5931 (cid_3025986 \| CHEMBL296468 \| N-(5-{[(5-tert-butyl-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase D2 (Human)	BDBM5931 (cid_3025986 \| CHEMBL296468 \| N-(5-{[(5-tert-butyl-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	3.90E+3	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase D3 (Human)	BDBM5931 (cid_3025986 \| CHEMBL296468 \| N-(5-{[(5-tert-butyl-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	750	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase 36 (Human)	BDBM5931 (cid_3025986 \| CHEMBL296468 \| N-(5-{[(5-tert-butyl-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	260	n/a	n/a	n/a	n/a	n/a
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TGF-beta receptor type-2 (Human)	BDBM5931 (cid_3025986 \| CHEMBL296468 \| N-(5-{[(5-tert-butyl-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	2.40E+3	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase DCLK1 (Human)	BDBM5931 (cid_3025986 \| CHEMBL296468 \| N-(5-{[(5-tert-butyl-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase DCLK2 (Human)	BDBM5931 (cid_3025986 \| CHEMBL296468 \| N-(5-{[(5-tert-butyl-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase DCLK3 (Human)	BDBM5931 (cid_3025986 \| CHEMBL296468 \| N-(5-{[(5-tert-butyl-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase 17A (Human)	BDBM5931 (cid_3025986 \| CHEMBL296468 \| N-(5-{[(5-tert-butyl-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	440	n/a	n/a	n/a	n/a	n/a
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Dual specificity tyrosine-phosphorylation-regulated kinase 1B (Human)	BDBM5931 (cid_3025986 \| CHEMBL296468 \| N-(5-{[(5-tert-butyl-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a
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Mitogen-activated protein kinase 6 (Human)	BDBM5931 (cid_3025986 \| CHEMBL296468 \| N-(5-{[(5-tert-butyl-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a
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Mitogen-activated protein kinase 4 (Human)	BDBM5931 (cid_3025986 \| CHEMBL296468 \| N-(5-{[(5-tert-butyl-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	4.10E+3	n/a	n/a	n/a	n/a	n/a
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Mitogen-activated protein kinase 7 (Human)	BDBM5931 (cid_3025986 \| CHEMBL296468 \| N-(5-{[(5-tert-butyl-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	650	n/a	n/a	n/a	n/a	n/a
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Glycogen synthase kinase-3 alpha (Human)	BDBM5931 (cid_3025986 \| CHEMBL296468 \| N-(5-{[(5-tert-butyl-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a
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Glycogen synthase kinase-3 beta (Human)	BDBM5931 (cid_3025986 \| CHEMBL296468 \| N-(5-{[(5-tert-butyl-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	37	n/a	n/a	n/a	n/a	n/a
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Interleukin-1 receptor-associated kinase 3 (Human)	BDBM5931 (cid_3025986 \| CHEMBL296468 \| N-(5-{[(5-tert-butyl-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	2.90E+6	n/a	n/a	n/a	n/a	n/a
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Myosin light chain kinase 3 (Human)	BDBM5931 (cid_3025986 \| CHEMBL296468 \| N-(5-{[(5-tert-butyl-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase PAK 3 (Human)	BDBM5931 (cid_3025986 \| CHEMBL296468 \| N-(5-{[(5-tert-butyl-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	3.50E+3	n/a	n/a	n/a	n/a	n/a
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Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (Human)	BDBM5931 (cid_3025986 \| CHEMBL296468 \| N-(5-{[(5-tert-butyl-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	3.80E+3	n/a	n/a	n/a	n/a	n/a
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Cyclin-A2/Cyclin-dependent kinase 2 (Human)	BDBM5931 (cid_3025986 \| CHEMBL296468 \| N-(5-{[(5-tert-butyl-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	52	n/a	n/a	n/a	n/a	n/a	n/a
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Cyclin-dependent kinase 2 (Human)	BDBM5931 (cid_3025986 \| CHEMBL296468 \| N-(5-{[(5-tert-butyl-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	48	n/a	n/a	n/a	n/a	n/a	n/a
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Cyclin-dependent kinase 9 (Human)	BDBM5931 (cid_3025986 \| CHEMBL296468 \| N-(5-{[(5-tert-butyl-...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
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