BindingDB PrimarySearch

BDBM60212 (4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-bis(oxidanyl)-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7-one;hydrochloride::(4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-dihydroxy-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7-one;hydrochloride::MLS000069607::NALTREXONE HYDROCHLORIDE::SMR000058767::US10988481, Compound NTX::US20240208984, Compound Naltrexone::US9107954, naltrexone::cid_5485201

SMILES: Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O

InChI Key: InChIKey=DQCKKXVULJGBQN-UHFFFAOYSA-N

Data: 193 KI 48 IC50 19 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 260 hits for monomerid = 60212
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Kappa-type opioid receptor (Human)	BDBM60212 (SMR000058767 \| NALTREXONE HYDROCHLORIDE \| MLS00006...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	174	n/a	n/a	n/a	n/a	n/a	n/a
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Mu-type opioid receptor (Human)	BDBM60212 (SMR000058767 \| NALTREXONE HYDROCHLORIDE \| MLS00006...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	8.90	n/a	n/a	n/a	n/a	n/a	n/a
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Bile salt export pump (Human)	BDBM60212 (SMR000058767 \| NALTREXONE HYDROCHLORIDE \| MLS00006...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
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Kappa-type opioid receptor (Guinea pig)	BDBM60212 (SMR000058767 \| NALTREXONE HYDROCHLORIDE \| MLS00006...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	9.5	n/a	n/a	n/a	n/a	n/a	n/a
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Mu-type opioid receptor (Human)	BDBM60212 (SMR000058767 \| NALTREXONE HYDROCHLORIDE \| MLS00006...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	n/a	0.380	n/a	n/a	n/a	n/a
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Mu-type opioid receptor (Mouse)	BDBM60212 (SMR000058767 \| NALTREXONE HYDROCHLORIDE \| MLS00006...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	n/a	0.160	n/a	n/a	n/a	n/a
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Mu-type opioid receptor (Human)	BDBM60212 (SMR000058767 \| NALTREXONE HYDROCHLORIDE \| MLS00006...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	3.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Kappa-type opioid receptor (Human)	BDBM60212 (SMR000058767 \| NALTREXONE HYDROCHLORIDE \| MLS00006...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	n/a	0.810	n/a	n/a	n/a	n/a
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Delta-type opioid receptor (Human)	BDBM60212 (SMR000058767 \| NALTREXONE HYDROCHLORIDE \| MLS00006...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	n/a	4.40	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Mu-type opioid receptor (Human)	BDBM60212 (SMR000058767 \| NALTREXONE HYDROCHLORIDE \| MLS00006...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	8.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Delta-type/Kappa-type/Mu-type opioid receptor (Rat)	BDBM60212 (SMR000058767 \| NALTREXONE HYDROCHLORIDE \| MLS00006...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	n/a	0.5	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Delta-type/Kappa-type/Mu-type opioid receptor (Human)	BDBM60212 (SMR000058767 \| NALTREXONE HYDROCHLORIDE \| MLS00006...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.550	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Delta-type/Kappa-type/Mu-type opioid receptor (Human)	BDBM60212 (SMR000058767 \| NALTREXONE HYDROCHLORIDE \| MLS00006...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.590	n/a	n/a	n/a	n/a	n/a	n/a
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Solute carrier family 22 member 1 (Human)	BDBM60212 (SMR000058767 \| NALTREXONE HYDROCHLORIDE \| MLS00006...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.58E+5	n/a	n/a	n/a	n/a	n/a	n/a
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Mu-type opioid receptor (Human)	BDBM60212 (SMR000058767 \| NALTREXONE HYDROCHLORIDE \| MLS00006...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	2.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Mu-type opioid receptor (Human)	BDBM60212 (SMR000058767 \| NALTREXONE HYDROCHLORIDE \| MLS00006...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	8.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Mu-type opioid receptor (Mouse)	BDBM60212 (SMR000058767 \| NALTREXONE HYDROCHLORIDE \| MLS00006...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	6.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Mu-type opioid receptor (Human)	BDBM60212 (SMR000058767 \| NALTREXONE HYDROCHLORIDE \| MLS00006...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	n/a	0.160	n/a	n/a	n/a	n/a
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Mu-type opioid receptor (Rat)	BDBM60212 (SMR000058767 \| NALTREXONE HYDROCHLORIDE \| MLS00006...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
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Delta-type opioid receptor (Human)	BDBM60212 (SMR000058767 \| NALTREXONE HYDROCHLORIDE \| MLS00006...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
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Mu-type opioid receptor (Guinea pig)	BDBM60212 (SMR000058767 \| NALTREXONE HYDROCHLORIDE \| MLS00006...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.730	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Kappa-type opioid receptor (Guinea pig)	BDBM60212 (SMR000058767 \| NALTREXONE HYDROCHLORIDE \| MLS00006...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	9.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Delta-type/Kappa-type/Mu-type opioid receptor (Human)	BDBM60212 (SMR000058767 \| NALTREXONE HYDROCHLORIDE \| MLS00006...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	5.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Kappa-type opioid receptor (Guinea pig)	BDBM60212 (SMR000058767 \| NALTREXONE HYDROCHLORIDE \| MLS00006...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Kappa-type opioid receptor (Guinea pig)	BDBM60212 (SMR000058767 \| NALTREXONE HYDROCHLORIDE \| MLS00006...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	47	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Delta-type opioid receptor (Rat)	BDBM60212 (SMR000058767 \| NALTREXONE HYDROCHLORIDE \| MLS00006...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	221	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Delta-type opioid receptor (Rat)	BDBM60212 (SMR000058767 \| NALTREXONE HYDROCHLORIDE \| MLS00006...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	5.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Mu-type opioid receptor (Rat)	BDBM60212 (SMR000058767 \| NALTREXONE HYDROCHLORIDE \| MLS00006...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
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Mu-type opioid receptor (Rat)	BDBM60212 (SMR000058767 \| NALTREXONE HYDROCHLORIDE \| MLS00006...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	6.80	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Kappa-type opioid receptor (Guinea pig)	BDBM60212 (SMR000058767 \| NALTREXONE HYDROCHLORIDE \| MLS00006...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	9.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Mu-type opioid receptor (Guinea pig)	BDBM60212 (SMR000058767 \| NALTREXONE HYDROCHLORIDE \| MLS00006...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.730	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Delta-type opioid receptor (Human)	BDBM60212 (SMR000058767 \| NALTREXONE HYDROCHLORIDE \| MLS00006...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Delta-type/Kappa-type/Mu-type opioid receptor (Human)	BDBM60212 (SMR000058767 \| NALTREXONE HYDROCHLORIDE \| MLS00006...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	5.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Kappa-type opioid receptor (Guinea pig)	BDBM60212 (SMR000058767 \| NALTREXONE HYDROCHLORIDE \| MLS00006...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.530	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Mu-type opioid receptor (Guinea pig)	BDBM60212 (SMR000058767 \| NALTREXONE HYDROCHLORIDE \| MLS00006...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.230	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Delta-type opioid receptor (Human)	BDBM60212 (SMR000058767 \| NALTREXONE HYDROCHLORIDE \| MLS00006...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Mu-type opioid receptor (Guinea pig)	BDBM60212 (SMR000058767 \| NALTREXONE HYDROCHLORIDE \| MLS00006...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Kappa-type opioid receptor (Guinea pig)	BDBM60212 (SMR000058767 \| NALTREXONE HYDROCHLORIDE \| MLS00006...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Delta-type opioid receptor (Human)	BDBM60212 (SMR000058767 \| NALTREXONE HYDROCHLORIDE \| MLS00006...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Mu-type opioid receptor (Human)	BDBM60212 (SMR000058767 \| NALTREXONE HYDROCHLORIDE \| MLS00006...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	n/a	0.590	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Delta-type opioid receptor (Human)	BDBM60212 (SMR000058767 \| NALTREXONE HYDROCHLORIDE \| MLS00006...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	n/a	5.40	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Kappa-type opioid receptor (Human)	BDBM60212 (SMR000058767 \| NALTREXONE HYDROCHLORIDE \| MLS00006...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	n/a	1.90	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Delta-type opioid receptor (Human)	BDBM60212 (SMR000058767 \| NALTREXONE HYDROCHLORIDE \| MLS00006...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	n/a	5.40	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Kappa-type opioid receptor (Human)	BDBM60212 (SMR000058767 \| NALTREXONE HYDROCHLORIDE \| MLS00006...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	n/a	1.90	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Mu-type opioid receptor (Human)	BDBM60212 (SMR000058767 \| NALTREXONE HYDROCHLORIDE \| MLS00006...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	n/a	n/a	0.590	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Delta-type opioid receptor (Human)	BDBM60212 (SMR000058767 \| NALTREXONE HYDROCHLORIDE \| MLS00006...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	5.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Kappa-type opioid receptor (Human)	BDBM60212 (SMR000058767 \| NALTREXONE HYDROCHLORIDE \| MLS00006...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Mu-type opioid receptor (Human)	BDBM60212 (SMR000058767 \| NALTREXONE HYDROCHLORIDE \| MLS00006...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	0.590	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Mu-type opioid receptor (Human)	BDBM60212 (SMR000058767 \| NALTREXONE HYDROCHLORIDE \| MLS00006...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	4.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA								Citation and Details
TBA				More data for this Ligand-Target Pair
Mu-type opioid receptor (Human)	BDBM60212 (SMR000058767 \| NALTREXONE HYDROCHLORIDE \| MLS00006...) Show SMILES Show InChI	GoogleScholar	UniChem	n/a	n/a	4.10	n/a	n/a	n/a	n/a	n/a	n/a
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