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BDBM60423 US9062048, 118

SMILES: CC(C)C1CC[C@@H](CC1)N1CC(C1)NC(=O)CNc1ncnc2ccc(cc12)C(C)(F)F

InChI Key: InChIKey=DDGRFRKRHPEXOC-GOENTQTQNA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 60423   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Monocyte chemotactic protein-1 (MCP-1)


(Homo sapiens (Human))
BDBM60423
PNG
(US9062048, 118)
Show SMILES CC(C)C1CC[C@@H](CC1)N1CC(C1)NC(=O)CNc1ncnc2ccc(cc12)C(C)(F)F
Show InChI InChI=1/C24H33F2N5O/c1-15(2)16-4-7-19(8-5-16)31-12-18(13-31)30-22(32)11-27-23-20-10-17(24(3,25)26)6-9-21(20)28-14-29-23/h6,9-10,14-16,18-19H,4-5,7-8,11-13H2,1-3H3,(H,30,32)(H,27,28,29)/t16?,19-
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 85n/an/an/an/an/an/a



Janssen Pharmaceutica NV

US Patent


Assay Description
Human monocytic cell line THP-1 cells were obtained from American Type Culture Collection (Manassas, Va., USA). The THP-1 cells were grown in RPMI-16...


US Patent US9062048 (2015)


BindingDB Entry DOI: 10.7270/Q2ZP44W1
More data for this
Ligand-Target Pair