BDBM60482 BDBM169108::US9079866, 509::US9745328, Compound 509::US9884878, Compound 509

SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccccc1C(=O)N1CCS(=O)(=O)CC1

InChI Key InChIKey=SAGCLNJHRTWHGT-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 60482   

TargetArachidonate 5-lipoxygenase-activating protein(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM60482(BDBM169108 | US9079866, 509 | US9884878, Compound ...)
Affinity DataKi:  147nMAssay Description:The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2016
Entry Details
US Patent

TargetArachidonate 5-lipoxygenase-activating protein(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM60482(BDBM169108 | US9079866, 509 | US9884878, Compound ...)
Affinity DataKi:  147nMAssay Description:The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2016
Entry Details
US Patent

TargetArachidonate 5-lipoxygenase-activating protein(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM60482(BDBM169108 | US9079866, 509 | US9884878, Compound ...)
Affinity DataKi:  147nMAssay Description:The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/5/2019
Entry Details
US Patent

TargetFlap endonuclease 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM60482(BDBM169108 | US9079866, 509 | US9884878, Compound ...)
Affinity DataKi:  147nMAssay Description:The FLAP binding assay is performed in HTRF format (homogeneous time resolved fluorescence). FLAP-containing membranes (1 μg/well final for huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent