BDBM60828 ABT-199::BDBM189459::US10213433, Compound 5::US10377755, Example ABT-199::US11318134, Example ABT-199::US11369599, Compound 369::US11590126, Example ABT-199::US11718611, Example T-7::US20240043404, Example 369::US20240166646, Example ABT-199::US9174982, 369

SMILES: CC1(CCC(=C(C1)c2ccc(cc2)Cl)CN3CCN(CC3)c4ccc(c(c4)Oc5cc6cc[nH]c6nc5)C(=O)NS(=O)(=O)c7ccc(c(c7)[N+](=O)[O-])NCC8CCOCC8)C

InChI Key: InChIKey=LQBVNQSMGBZMKD-UHFFFAOYSA-N

Data: 23 KI  10 IC50  6 Kd

PDB links: 4 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 39 hits for monomerid = 60828   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Bcl-2-like protein 1 (Human)	BDBM60828 (BDBM189459 | US9174982, 369 | ABT-199 | US10213433...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Human)	BDBM60828 (BDBM189459 | US9174982, 369 | ABT-199 | US10213433...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	0.420	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Human)	BDBM60828 (BDBM189459 | US9174982, 369 | ABT-199 | US10213433...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bcl2-associated agonist of cell death (Human)	BDBM60828 (BDBM189459 | US9174982, 369 | ABT-199 | US10213433...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Human)	BDBM60828 (BDBM189459 | US9174982, 369 | ABT-199 | US10213433...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bcl2-associated agonist of cell death (Human)	BDBM60828 (BDBM189459 | US9174982, 369 | ABT-199 | US10213433...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Human)	BDBM60828 (BDBM189459 | US9174982, 369 | ABT-199 | US10213433...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bcl-2-like protein 1 (Human)	BDBM60828 (BDBM189459 | US9174982, 369 | ABT-199 | US10213433...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Human)	BDBM60828 (BDBM189459 | US9174982, 369 | ABT-199 | US10213433...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Human)	BDBM60828 (BDBM189459 | US9174982, 369 | ABT-199 | US10213433...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Human)	BDBM60828 (BDBM189459 | US9174982, 369 | ABT-199 | US10213433...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Human)	BDBM60828 (BDBM189459 | US9174982, 369 | ABT-199 | US10213433...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	4.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Isoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL) (Human)	BDBM60828 (BDBM189459 | US9174982, 369 | ABT-199 | US10213433...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Induced myeloid leukemia cell differentiation protein Mcl-1 (Human)	BDBM60828 (BDBM189459 | US9174982, 369 | ABT-199 | US10213433...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bcl-2-related protein A1 [1-149] (Human)	BDBM60828 (BDBM189459 | US9174982, 369 | ABT-199 | US10213433...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bcl-2-like protein 1 (Human)	BDBM60828 (BDBM189459 | US9174982, 369 | ABT-199 | US10213433...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Human)	BDBM60828 (BDBM189459 | US9174982, 369 | ABT-199 | US10213433...) Show SMILES Show InChI	GoogleScholar	UniChem		<0.0100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Human)	BDBM60828 (BDBM189459 | US9174982, 369 | ABT-199 | US10213433...) Show SMILES Show InChI	GoogleScholar	UniChem		<0.0100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Human)	BDBM60828 (BDBM189459 | US9174982, 369 | ABT-199 | US10213433...) Show SMILES Show InChI	GoogleScholar	UniChem		<0.0100	<-15.0	n/a	n/a	n/a	n/a	n/a	n/a	25
TBA									Citation and Details
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Human)	BDBM60828 (BDBM189459 | US9174982, 369 | ABT-199 | US10213433...) Show SMILES Show InChI	GoogleScholar	UniChem		<0.0100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Human)	BDBM60828 (BDBM189459 | US9174982, 369 | ABT-199 | US10213433...) Show SMILES Show InChI	GoogleScholar	UniChem		<0.0100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Human)	BDBM60828 (BDBM189459 | US9174982, 369 | ABT-199 | US10213433...) Show SMILES Show InChI	GoogleScholar	UniChem		<0.0100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Human)	BDBM60828 (BDBM189459 | US9174982, 369 | ABT-199 | US10213433...) Show SMILES Show InChI	GoogleScholar	UniChem		0.0360	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Human)	BDBM60828 (BDBM189459 | US9174982, 369 | ABT-199 | US10213433...) Show SMILES Show InChI	GoogleScholar	UniChem		0.180	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Human)	BDBM60828 (BDBM189459 | US9174982, 369 | ABT-199 | US10213433...) Show SMILES Show InChI	GoogleScholar	UniChem		0.640	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Human)	BDBM60828 (BDBM189459 | US9174982, 369 | ABT-199 | US10213433...) Show SMILES Show InChI	GoogleScholar	UniChem		0.860	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Human)	BDBM60828 (BDBM189459 | US9174982, 369 | ABT-199 | US10213433...) Show SMILES Show InChI	GoogleScholar	UniChem		0.880	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Human)	BDBM60828 (BDBM189459 | US9174982, 369 | ABT-199 | US10213433...) Show SMILES Show InChI	GoogleScholar	UniChem		0.900	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Human)	BDBM60828 (BDBM189459 | US9174982, 369 | ABT-199 | US10213433...) Show SMILES Show InChI	GoogleScholar	UniChem		1.03	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Human)	BDBM60828 (BDBM189459 | US9174982, 369 | ABT-199 | US10213433...) Show SMILES Show InChI	GoogleScholar	UniChem		1.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Human)	BDBM60828 (BDBM189459 | US9174982, 369 | ABT-199 | US10213433...) Show SMILES Show InChI	GoogleScholar	UniChem		1.71	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bcl-2-like protein 1 (Human)	BDBM60828 (BDBM189459 | US9174982, 369 | ABT-199 | US10213433...) Show SMILES Show InChI	GoogleScholar	UniChem		>100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bcl-2-like protein 1 (Human)	BDBM60828 (BDBM189459 | US9174982, 369 | ABT-199 | US10213433...) Show SMILES Show InChI	GoogleScholar	UniChem		>100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bcl-2-like protein 1 (Human)	BDBM60828 (BDBM189459 | US9174982, 369 | ABT-199 | US10213433...) Show SMILES Show InChI	GoogleScholar	UniChem		>100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bcl-2-like protein 1 (Human)	BDBM60828 (BDBM189459 | US9174982, 369 | ABT-199 | US10213433...) Show SMILES Show InChI	GoogleScholar	UniChem		>100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bcl-2-like protein 1 (Human)	BDBM60828 (BDBM189459 | US9174982, 369 | ABT-199 | US10213433...) Show SMILES Show InChI	GoogleScholar	UniChem		>100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bcl-2-like protein 1 (Human)	BDBM60828 (BDBM189459 | US9174982, 369 | ABT-199 | US10213433...) Show SMILES Show InChI	GoogleScholar	UniChem		>100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bcl-2-like protein 1 (Human)	BDBM60828 (BDBM189459 | US9174982, 369 | ABT-199 | US10213433...) Show SMILES Show InChI	GoogleScholar	UniChem		>100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Bcl-2-like protein 1 (Human)	BDBM60828 (BDBM189459 | US9174982, 369 | ABT-199 | US10213433...) Show SMILES Show InChI	GoogleScholar	UniChem		>100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair