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BDBM6406 N-(5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyridin-3-yl)-4-(dimethylamino)benzamide::N-{5-[6-(3-Chloro-phenylamino)-pyrazin-2-yl]-pyridin-3-yl}-4-(dimethylamino)-benzamide::Pyrazine-Pyridine Biheteroaryl 49

SMILES: CN(C)c1ccc(cc1)C(=O)Nc1cncc(c1)-c1cncc(Nc2cccc(Cl)c2)n1

InChI Key: InChIKey=MKQUABVRXBYMTD-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 6406   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
VEGFR-2 (KDR)


(Rattus norvegicus (rat))
BDBM6406
PNG
(N-(5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyridi...)
Show SMILES CN(C)c1ccc(cc1)C(=O)Nc1cncc(c1)-c1cncc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C24H21ClN6O/c1-31(2)21-8-6-16(7-9-21)24(32)29-20-10-17(12-26-13-20)22-14-27-15-23(30-22)28-19-5-3-4-18(25)11-19/h3-15H,1-2H3,(H,28,30)(H,29,32)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
BindingDB Entry DOI: 10.7270/Q2NC5ZD5
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 1 (CDK1)


(Homo sapiens (Human))
BDBM6406
PNG
(N-(5-{6-[(3-chlorophenyl)amino]pyrazin-2-yl}pyridi...)
Show SMILES CN(C)c1ccc(cc1)C(=O)Nc1cncc(c1)-c1cncc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C24H21ClN6O/c1-31(2)21-8-6-16(7-9-21)24(32)29-20-10-17(12-26-13-20)22-14-27-15-23(30-22)28-19-5-3-4-18(25)11-19/h3-15H,1-2H3,(H,28,30)(H,29,32)
PDB
MMDB

Reactome pathway
KEGG

DrugBank
GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical



Assay Description
The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...


J Med Chem 48: 4892-909 (2005)


Article DOI: 10.1021/jm058205b
BindingDB Entry DOI: 10.7270/Q2NC5ZD5
More data for this
Ligand-Target Pair