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BDBM6504 4-Anilino-3-cyanoquinoline deriv. 7a::4-[(4-ethoxy-3,5-dimethoxyphenyl)amino]-6,7-dimethoxyquinoline-3-carbonitrile

SMILES: CCOc1c(OC)cc(Nc2c(cnc3cc(OC)c(OC)cc23)C#N)cc1OC

InChI Key: InChIKey=AJHAZHZGPDMIEF-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 6504   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM6504
PNG
(4-Anilino-3-cyanoquinoline deriv. 7a | 4-[(4-ethox...)
Show SMILES CCOc1c(OC)cc(Nc2c(cnc3cc(OC)c(OC)cc23)C#N)cc1OC
Show InChI InChI=1S/C22H23N3O5/c1-6-30-22-19(28-4)7-14(8-20(22)29-5)25-21-13(11-23)12-24-16-10-18(27-3)17(26-2)9-15(16)21/h7-10,12H,6H2,1-5H3,(H,24,25)
PDB
MMDB

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Similars

Article
PubMed
n/an/a 63n/an/an/an/a7.530



Wyeth-Ayerst Research



Assay Description
Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...


Bioorg Med Chem Lett 10: 2477-80 (2000)


Article DOI: 10.1016/S0960-894X(00)00493-5
BindingDB Entry DOI: 10.7270/Q20P0X7T
More data for this
Ligand-Target Pair