BDBM653210 4-(1,6-dimethyl-1H- indazol-7-yl)-7,7-dimethyl- 2-(2-(2-propenoyl)-2,6- diazaspiro[3.4]octan-6-yl)- 5,6,7,8-tetrahydro-1,6- naphthyridine-3-carbonitrile::US20240059703, Example 13-138

SMILES Cc1ccc2cnn(C)c2c1-c1c2CNC(C)(C)Cc2nc(N2CCC3(CN(C3)C(=O)C=C)C2)c1C#N

InChI Key InChIKey=DIPPSBRBIRCCET-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 653210   

LigandPNGBDBM653210(US20240059703, Example 13-138 | 4-(1,6-dimethyl-1H...)
Affinity DataIC50: 641nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
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Date in BDB:
4/24/2024
Entry Details
US Patent