BDBM653211 (7R)-4-(1,6-dimethyl-1H- indazol-7-yl)-7-methyl-2- (2-(2-propenoyl)-2,6- diazaspiro[3.4]octan-6-yl)- 7,8-dihydro-5H-pyrano[4,3- b]pyridine-3-carbonitrile::US20240059703, Example 13-139::US20240059703, Example 13-140

SMILES CC1Cc2nc(N3CCC4(CN(C4)C(=O)C=C)C3)c(C#N)c(c2CO1)-c1c(C)ccc2cnn(C)c12

InChI Key InChIKey=JRRHNXIXEYYBGG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 653211   

LigandPNGBDBM653211(US20240059703, Example 13-139 | US20240059703, Exa...)
Affinity DataIC50: 388nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent

LigandPNGBDBM653211(US20240059703, Example 13-139 | US20240059703, Exa...)
Affinity DataIC50: 1.67E+5nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2024
Entry Details
US Patent