BDBM653325 1-(6-((7R)-4-(2- chlorophenyl)-7-(1,4- dimethyl-1H-pyrazol-5- yl)-3-methyl-5,6,7,8- tetrahydro-2-quinolinyl)- 2,6-diazaspiro[3.4]octan- 2-yl)-2-propen-1-one::US20240059703, Example 14-96

SMILES Cc1cnn(C)c1C1CCc2c(C1)nc(N1CCC3(CN(C3)C(=O)C=C)C1)c(C)c2-c1ccccc1Cl

InChI Key InChIKey=PMIUMQQTRMDVMH-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 653325   

LigandPNGBDBM653325(US20240059703, Example 14-96 | 1-(6-((7R)-4-(2- ch...)
Affinity DataIC50: 546nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
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Date in BDB:
4/24/2024
Entry Details
US Patent